Pliocene felsic rift margin and Quaternary rift center volcanic rocks from the northern Main Ethiopian Rift (MER) exhibit contrasts in major and trace element contents and Sr-Nd isotopic ratios. Quaternary rift center felsic volcanic rocks are mainly peralkaline trachytes and rhyolites, whereas Pliocene felsic rift margin volcanic rocks are represented by benmoreites, weakly peralkaline trachytes and rare rhyolites.Most of the felsic rift margin volcanic rocks have greater Al 2 O 3 , K 2 O, Nb, Zr, Rb, and Sr, and lesser CaO, Zr/Nb, and CaO/Al 2 O 3 than rift center volcanic rocks. These contrasts may have been inherited from differences in the compositions of their parental basic magmas, which were produced by variable degrees of partial melting.In both series, the felsic volcanic rocks generally have higher initial Sr-isotopic (0.7038-0.7073) ratios than their basic equivalents (0.7035-0.7046). Nd-isotopic ratios of most felsic rift center samples (0.5129-0.5126) are similar to their associated basic volcanic rocks. In contrast, the Ndisotopic ratios (0.5128-0.5124) of felsic rift margin volcanic rocks are commonly lower than their companion basic volcanic rocks (0.512806-0.512893), and are relatively lower than rift center equivalents. The elemental and Sr-Nd isotopic compositions of the volcanic rocks suggest that fractional crystallization from differing basic parents accompanied by a limited assimilation (AFC) was the dominant process controlling the genesis of the MER felsic volcanic rocks.