Spatial arrangement of selected fluorescence labels in lipid bilayer

Zawada, Zygmunt H.

doi:10.1016/j.jphotobiol.2013.05.001

Journal of Photochemistry and Photobiology B: Biology

2013

DOI: 10.1016/j.jphotobiol.2013.05.001

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Spatial arrangement of selected fluorescence labels in lipid bilayer

Zygmunt H. Zawada

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Cited by 2 publications

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“…Rhodamine B is hydrophilic and has strong interaction with the lipid bilayer. 26 Therefore, Rhodamine B is expected to be localized in the lipid bilayer and Pluronic shell of multilayer NPs. As shown in Figure 7A and B, rapid cellular uptake of multilayer NPs was observed irrespective of dyes, and the similar pattern of cellular uptake indicated that most of the DTX moved to the cytosol during the cellular uptake of multilayer NPs.…”

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confidence: 99%

Docetaxel-loaded multilayer nanoparticles with nanodroplets for cancer therapy

Oh¹,

Kim²,

Yoon³

et al. 2016

IJN

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A mixture of docetaxel (DTX) and Solutol ® HS 15 (Solutol) transiently formed nanodroplets when it was suspended in an aqueous medium. However, nanodroplets that comprised DTX and Solutol showed a rapid precipitation of DTX because of their unstable characteristics in the aqueous medium. The incorporation of nanodroplets that comprised DTX and Solutol through vesicle fusion and subsequent stabilization was designed to prepare multilayer nanoparticles (NPs) with a DTX-loaded Solutol nanodroplet (as template NPs) core for an efficient delivery of DTX as a chemotherapeutic drug. As a result, the DTX-loaded Solutol nanodroplets (~11.7 nm) were observed to have an increased average diameter (from 11.7 nm to 156.1 nm) and a good stability of the hydrated NPs without precipitation of DTX by vesicle fusion and multilayered structure, respectively. Also, a long circulation of the multilayer NPs was observed, and this was due to the presence of Pluronic F-68 on the surface of the multilayer NPs. This led to an improved antitumor efficacy based on the enhanced permeation and retention effect. Therefore, this study indicated that the multilayer NPs have a considerable potential as a drug delivery system with an enhanced therapeutic efficacy by blood circulation and with low side effects.

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confidence: 99%

Docetaxel-loaded multilayer nanoparticles with nanodroplets for cancer therapy

Oh¹,

Kim²,

Yoon³

et al. 2016

IJN

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Determination of the fluorescence labels location in lipid bilayer based on fluorescence quenching

Pentak

Zawada

Szkudlarek

et al. 2018

Journal of Molecular Liquids

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Spatial arrangement of selected fluorescence labels in lipid bilayer

Cited by 2 publications

References 23 publications

Docetaxel-loaded multilayer nanoparticles with nanodroplets for cancer therapy

Docetaxel-loaded multilayer nanoparticles with nanodroplets for cancer therapy

Determination of the fluorescence labels location in lipid bilayer based on fluorescence quenching

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