2020
DOI: 10.1111/head.14017
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Spatial aspects of pain modulation are not disrupted in adolescents with migraine

Abstract: Objective: To compare spatial pain modulation capabilities between adolescents with and without migraine. Background: Conditioned pain modulation (CPM) responses at the leg are similar in adolescents with versus without migraine. However, the anatomical region of testing may affect spatial pain modulation capabilities as differences in nociceptive processing between patients with migraine and healthy controls are found in local areas that are near the site of clinical pain but not in nonlocal areas. This study… Show more

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Cited by 9 publications
(11 citation statements)
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“…This manuscript includes data from eight different studies including unpublished studies, involving psychological and experimental pain outcome parameters [7,8,54,57]. For psychological measures, we focused on anxiety, depression and pain catastrophizing.…”
Section: Methodsmentioning
confidence: 99%
“…This manuscript includes data from eight different studies including unpublished studies, involving psychological and experimental pain outcome parameters [7,8,54,57]. For psychological measures, we focused on anxiety, depression and pain catastrophizing.…”
Section: Methodsmentioning
confidence: 99%
“…This study is not related to previously published studies from our group. [26][27][28] There are no other publications related to this dataset (from healthy adolescents or patients).…”
Section: Materials S and Me Thodsmentioning
confidence: 99%
“…Interestingly, the CPM effect duration after termination of the conditioning stimulus seems to be relatively short, varying from 0 to 10 min ( Imai et al, 2016 ; Lewis et al, 2012 ; Vaegter, Handberg & Graven-Nielsen, 2016 ). Local, regional and remote locations are often selected in clinical studies to differentiate between primary, secondary, or widespread hyperalgesia or gain of nerve fibre function ( Courtney et al, 2016 ; Nahman-Averbuch et al, 2020 ; Ng et al, 2014 ; Owens et al, 2016 ; Vaegter, Handberg & Graven-Nielsen, 2014 ). Therefore, the application of test stimuli on multiple locations takes time, which may justify using a parallel design where the duration of the conditioning stimulus can be extended until the last test stimulus ( Pud, Granovsky & Yarnitsky, 2009 ).…”
Section: Introductionmentioning
confidence: 99%