Spatial but not object recognition is impaired by aging in rats

Cavoy, Albert; Delacour, Jean

doi:10.1016/0031-9384(93)90148-9

Cited by 100 publications

(52 citation statements)

References 25 publications

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“…Similarly, deficits were observed in tasks that demanded memory for the relative recency ("working memory") of one of two levers (Dunnett et al 1988), light intensities (Winocur 1991 ) or conditional cue locations (Winocur 1992). In contrast, delay-dependent postacquisition performance was not impaired in tasks that employed nonrepeating (Aggleton et al 1989;Cavoy and Delacour 1993) or seldom-repeating (this study) discrete stimuli. The only exception to this characterization of the combined results is the absence of a delay-dependent deficit for spatial cues in the Aggleton et al (1989) study.…”

Section: Age-related Selective Impairment On Cdnm Acquistioncontrasting

confidence: 61%

“…For example, in the Cavoy and Delacour (1993) study, in contrast to the sparing of delayed object recognition, the same aged subjects were severely impaired in delayed (90 sec) recognition of an arm in a spatial maze. Also, Dunnett et al (1988) reported that 15-and 24-month-old rats had a delay-dependent deficit in matching and nonmatching to sample in a task where rats had to remember which of two retractable levers was presented: In this study aged animals were not impaired during initial acquisition of the task when no delay was imposed between the sample and match stimulus presentations.…”

Section: Age-related Selective Impairment On Cdnm Acquistionmentioning

confidence: 85%

“…In that study aged rats were also impaired in acquisition but not delay performance of a delayed nonmatch-to-sampie task where the cues were one of two turns in a T-maze. In addition, Cavoy and Delacour (1993) found that 18-and 24-month-old rats demonstrated preserved delayed retention, even at rather long (300 sec) intervals, in task where reduced exploration during representation of a previously novel object was used as a measure of recognition.…”

Section: Age-related Selective Impairment On Cdnm Acquistionmentioning

confidence: 99%

See 2 more Smart Citations

Cognitive decline associated with normal aging in rats: a neuropsychological approach.

Zyzak¹,

Otto²,

Eichenbaum³

et al. 1995

Learn. Mem.

102

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The effects of aging on cognitive capacities were examined by comparing the performance of young and old rats on tasks characterized as dependent on different brain systems. This neuropsychological approach was employed to determine the extent to which multiple neural systems are compromised in aging and whether deterioration of one system correlates with that of another. The two tasks used in the present study were an odor-guided recognition memory task, for which different aspects of performance have been shown to be dependent on the integrity of the orbital prefrontal and perirhinal-entorhinal cortex, and the Morris water maze, for which performance depends on the medial prefrontal cortex and hippocampus. Rats were trained on the recognition memory task under minimal memory load and then challenged with longer memory delays and higher levels of inter-item interference. Considerable variation was observed in the performance of aged rats on acquisition of the recognition memory task, and unlike young rats, some aged rats could not acquire the task. Nevertheless, those aged rats who did acquire the cDNM task performed as well as young animals when the memory delay was extended and interference was elevated. In addition, consistent with previous findings, the performance of the same aged rats was highly variable in the Morris water maze task.' Furthermore, although correlations between scores on the two tasks for indiyidual aged rats were not reliable, only those aged rats that performed outside the performance range of young rats in the water maze were impaired on acquisition of the recognition memory task. This pattern of findings is consistent with age-related dysfunction in multiple subdivisions of the prefrontal cortex as well as the hippocampus and suggests that these brain regions may deteriorate in the same subgroup of aged rats.

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Section: Age-related Selective Impairment On Cdnm Acquistioncontrasting

confidence: 61%

Section: Age-related Selective Impairment On Cdnm Acquistionmentioning

confidence: 85%

Section: Age-related Selective Impairment On Cdnm Acquistionmentioning

confidence: 99%

See 1 more Smart Citation

Cognitive decline associated with normal aging in rats: a neuropsychological approach.

Zyzak¹,

Otto²,

Eichenbaum³

et al. 1995

Learn. Mem.

102

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show abstract

“…There is agreement on the age-related retention deficits with delays .24 h (Bartolini et al 1996;de Lima et al 2005;Pieta Dias et al 2007; Burke et al 2010;Leite et al 2011), but not at short retention intervals. Although some investigators found no age-related impairment in SOR memory testing at 1-min (Lukaszewska and Radulska 1994), 2-min (Burke et al 2010), 3-min (Bergado et al 2011), 5-min (Cavoy and Delacour 1993), and 1.5-h delays (de Lima et al 2005;Pieta Dias et al 2007; Leite et al 2011), there are studies reporting deficits in aged rats at 2 h (Burke et al 2010), 1 h (Scali et al 1994Vannucchi et al 1997;Pitsikas et al 2005; Da Silva Costa-Aze et al 2011) and even at 60-or 30-sec retention periods (Willig et al 1987;Bartolini et al 1996).…”

mentioning

confidence: 99%

“…In Experiment 1 we used standard objects that differed in material, shape, size, and color. Aging studies using SOR tasks have applied a great variety of standard objects (Aggleton et al 1989;Lukaszewska and Radulska 1994;Liu et al 2004;Hauser et al 2009), since the use of clearly different elemental stimuli is common (Cavoy and Delacour 1993;Burke et al 2010;Bergado et al 2011). However, they are often poorly described and not easily found all over the world, rendering it difficult to replicate the experiments.…”

mentioning

confidence: 99%

Spontaneous object recognition memory in aged rats: Complexity versus similarity

Gámiz

Gallo

2012

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Previous work on the effect of aging on spontaneous object recognition (SOR) memory tasks in rats has yielded controversial results. Although the results at long-retention intervals are consistent, conflicting results have been reported at shorter delays. We have assessed the potential relevance of the type of object used in the performance of aged rats in SOR tasks. Using standard objects, 24-mo-old rats did not exhibit retention impairment at a 1-h delay. At this retention interval no differences between young and old rats were found in a high-similarity SOR task, but aged rats exhibited deficits when clearly different complex forms were applied.

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Early age‐dependent impairments of context‐dependent extinction learning, object recognition, and object‐place learning occur in rats

2013

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The hippocampus is vulnerable to age-dependent memory decline. Multiple forms of memory depend on adequate hippocampal function. Extinction learning comprises active inhibition of no longer relevant learned information concurrent with suppression of a previously learned reaction. It is highly dependent on context, and evidence exists that it requires hippocampal activation. In this study, we addressed whether context-based extinction as well as hippocampus-dependent tasks, such as object recognition and object-place recognition, are equally affected by moderate aging. Young (7-8 week old) and older (7-8 month old) Wistar rats were used. For the extinction study, animals learned that a particular floor context indicated that they should turn into one specific arm (e.g., left) to receive a food reward. On the day after reaching the learning criterion of 80% correct choices, the floor context was changed, no reward was given and animals were expected to extinguish the learned response. Both, young and older rats managed this first extinction trial in the new context with older rats showing a faster extinction performance. One day later, animals were returned to the T-maze with the original floor context and renewal effects were assessed. In this case, only young but not older rats showed the expected renewal effect (lower extinction ratio as compared to the day before). To assess general memory abilities, animals were tested in the standard object recognition and object-place memory tasks. Evaluations were made at 5 min, 1 h and 7 day intervals. Object recognition memory was poor at short-term and intermediate time-points in older but not young rats. Object-place memory performance was unaffected at 5 min, but impaired at 1 h in older but not young rats. Both groups were impaired at 7 days. These findings support that not only aspects of general memory, but also context-dependent extinction learning, are affected by moderate aging. This may reflect less flexibility in revising hard-wired knowledge or reduced adaptability to new learning challenges.

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Spatial but not object recognition is impaired by aging in rats

Cited by 100 publications

References 25 publications

Cognitive decline associated with normal aging in rats: a neuropsychological approach.

Cognitive decline associated with normal aging in rats: a neuropsychological approach.

Spontaneous object recognition memory in aged rats: Complexity versus similarity

Early age‐dependent impairments of context‐dependent extinction learning, object recognition, and object‐place learning occur in rats

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