GIS plays a crucial role in helping decision-makers to analyze and interpret complex spatial data to make informed decisions. However, conventional GIS workflows are inadequate for managing the massive amounts of spatial data that are necessary for decision-making. This chapter discussed the transformative potential of AI and spatial data in enhancing spatial intelligence. It first outlined the challenges associated with GIS, specifically related to data management and decision-making. These challenges are categorized into technical, data, and human-centered. Next, the chapter presented AI-based strategies that can be used to address these challenges, along with their potential impact. The chapter also examined the ethical considerations surrounding AI-powered GIS and suggested approaches to address them. This chapter can serve as a valuable source of information for researchers, practitioners, and policymakers operating in the realm of AI-based GIS.