Groundwater contamination is a major concern in front of the scienti c community because it is directly related to human health, especially in arid and semiarid regions. Therefore, a comprehensive study was engaged to evaluate the water quality, potability, and human health risk assessment due to the consumption of uoride and nitrate-contaminated water in Jhunjhunu district of Rajasthan. In water quality, 16 parameters were analyzed as per the standard method of APHA(American Public health Association ), 2017, collected from 87 locations in the study region, and results found that the value of the number of quality parameters consisting of pH, EC, TDS, uoride, chloride, nitrate, sulphate, total hardness, calcium, magnesium, and total alkalinity was observed higher than the recommended limit of BIS (Bureau of Indian standard), 2012 and WHO (World Health Organization), 2017. The uoride in 11% and nitrate in 6% samples were observed to exceed the permissible limit of WHO. The results of risk assessment due to uoride and nitrate revealed that Hazard Index values of 71% groundwater samples for males, 78% groundwater samples for females, and 75% groundwater samples for children were greater than 1, indicating the signi cant health hazard due to consumption of groundwater. The water quality index (WQI) found that 37% of groundwater samples belong to categories that cannot be used for drinking purposes. Principal component analysis (PCA) reduced the large number of variables affecting the overall quality and chemistry of groundwater and determined four major components which account for 69.50% variance in the data.