Spatial distributions of Anopheles species in relation to malaria incidence at 70 localities in the highly endemic Northwest and South Pacific coast regions of Colombia

Ahumada, Martha Liliana; Orjuela, Lorena I.; Pareja, Paula Ximena; Conde, Marcela; Cabarcas, Diana M.; Cubillos, Eliana Fernanda Galindo; López, Jorge; Beier, John C.; Herrera, Sócrates; Quiñónes, Martha L.

doi:10.1186/s12936-016-1421-4

Cited by 44 publications

(44 citation statements)

References 47 publications

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“…nuñeztovari, and Ny. albitarsis (Sinka et al, 2012;Conn et al, 2013;Fernández et al, 2014;Laporta et al, 2015;Ahumada et al, 2016) are all implicated as vectors of P. vivax (da Silva et al, 2006;Neves et al, 2013;Rios-Velasquez et al, 2013;Hurtado et al, 2018;Martins-Campos et al, 2018;Prussing et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Ookinete-Specific Genes and 18S SSU rRNA Evidenced in Plasmodium vivax Selection and Adaptation by Sympatric Vectors

González-Cerón¹,

Rodrı́guez²,

Ovilla-Muñoz³

et al. 2020

Front. Genet.

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In the southern Pacific coast of Chiapas, Mexico (SM), the two most abundant vector species, Nyssorhynchus albimanus and Anopheles pseudopunctipennis, were susceptible to different Plasmodium vivax Pvs25/28 haplotypes. To broaden our understanding of the existing P. vivax in the area, genes encoding proteins relevant for ookinete development and the 18S rRNA were studied. P. vivax infectivity (percentage of infected mosquitoes and oocyst numbers) was evaluated by simultaneously feeding infected blood samples from patients to Ny. albimanus and An. pseudopunctipennis female mosquitoes. Three infectivity patterns were identified: one group of parasites were more infective to An. pseudopunctipennis than to Ny. albimanus, another group was more infective to Ny. albimanus, while a third group infected both vectors similarly. In 29 parasite isolates, the molecular variations of ookinete-specific genes and the 18S rRNA-type S were analyzed. Using concatenated sequences, phylogenetic trees, and Structure analysis, parasite clustering within SM isolates and between these and those from other geographical origins were investigated. A ML phylogenetic tree resolved two parasite lineages: PvSM-A and PvSM-B. They were associated to a different 18S rRNA variant. PvSM-A parasites had 18S rRNA variant rV2 and correspond to parasites causing high oocyst infection in Ny. albimanus. A new ML tree and Structure analysis, both comprising global sequences, showed PvSM-A clustered with Latin American parasites. Meanwhile, all isolates of PvSM-B had 18S rRNA variant rV1 and remained as unique genetic cluster comprising two subgroups: PvSM-Ba, producing high infection in An. pseudopunctipennis, and PvSM-Bb, causing similar oocyst infection in both vector species. PvSM-A parasites were genetically similar to parasites from South America.Meanwhile, PvSM-B were exclusive to southern Mexico and share ancestry with Asian parasites. The results suggest that these lineages evolved separately, likely by geographic and vector restriction.

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Section: Discussionmentioning

confidence: 99%

Ookinete-Specific Genes and 18S SSU rRNA Evidenced in Plasmodium vivax Selection and Adaptation by Sympatric Vectors

González-Cerón¹,

Rodrı́guez²,

Ovilla-Muñoz³

et al. 2020

Front. Genet.

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“…This number of species and the number of collected specimens is small when taking into account that 47 species of Anopheles are recorded in the country [43], 20 species are known to occur in the Department [23] from the 47 species of Anopheles recorded in the country [45], and that previous studies have collected thousands of Anopheles using human-landing catches [11, 36]. Regarding collection numbers and species composition, this could be affected by the use of light traps or traps artificially baited.…”

Section: Discussionmentioning

confidence: 99%

“…Research on the eco-epidemiology of the disease in Colombia usually is made as a part of outbreak responses or short-term research programmes aiming to reduce the number of cases at a local scale [8–11]. Those studies highlight the entomological surveillance as a useful tool when planning strategies for malaria control.…”

Section: Introductionmentioning

confidence: 99%

Entomological characterization of malaria in northern Colombia through vector and parasite species identification, and analyses of spatial distribution and infection rates

González

Molina

León

et al. 2017

Malar J

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BackgroundMalaria remains a worldwide public health concern and, in Colombia, despite the efforts to stop malaria transmission, the incidence of cases has increased over the last few years. In this context, it is necessary to evaluate vector diversity, infection rates, and spatial distribution, to better understand disease transmission dynamics. This information may contribute to the planning and development of vector control strategies.ResultsA total of 778 Anopheles mosquitoes were collected in fifteen localities of Córdoba from August 2015 to October 2016. Six species were identified and overall, Anopheles albimanus was the most widespread and abundant species (83%). Other species of the Nyssorhynchus subgenus were collected, including Anopheles triannulatus (13%), Anopheles nuneztovari (1%), Anopheles argyritarsis (< 1%) and two species belonging to the Anopheles subgenus: Anopheles pseudopunctipennis (3%) and Anopheles neomaculipalpus (< 1%). Four species were found naturally infected with two Plasmodium species: Anopheles nuneztovari was detected naturally infected with Plasmodium falciparum and Anopheles pseudopunctipennis with Plasmodium vivax, whereas An. albimanus and An. triannulatus were found infected with both parasite species and confirmed by nested PCR.ConclusionsIn general, the obtained results were contrasting with previous studies in terms of the most abundant and widespread collected species, and regarding infection rates, which were higher than those previously reported. A positive relationship between mosquito local abundance at the locality level and human infection at the municipality level was found. Mosquito local abundance and the number of houses with mosquitoes in each village are factors explaining malaria human cases in these villages. The obtained results suggest that other factors related to the apparent variation in malaria eco-epidemiology in northern Colombia, must be identified, to provide health authorities with better decision tools aiming to design control and prevention strategies.Electronic supplementary materialThe online version of this article (doi:10.1186/s12936-017-2076-5) contains supplementary material, which is available to authorized users.

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“…neivai s.1. have been detected in the vicinities of both cities [44, 48], the species distributions in the vicinities of Buenaventura and Tumaco differ more than those in the vicinities of Tumaco and Guapi [48]. As such, heterogeneous vectorial capacity seems an unlikely alternative hypothesis.…”

Section: Discussionmentioning

confidence: 99%

Identity-by-descent relatedness estimates with uncertainty characterise departure from isolation-by-distance betweenPlasmodium falciparumpopulations on the Colombian-Pacific coast

Taylor

Echeverry

Anderson

et al. 2020

Preprint

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18Characterising connectivity between geographically separated biological populations is a common goal in 19 many fields. Recent approaches to understanding connectivity between malaria parasite populations, with 20 implications for disease control efforts, have used estimates of relatedness based on identity-by-descent (IBD). 21 However, uncertainty around estimated relatedness has not been accounted for to date. IBD-based relat-22 edness estimates with uncertainty were computed for pairs of monoclonal Plasmodium falciparum samples 23 collected from five cities on the Colombian-Pacific coast where long-term clonal propagation of P. falciparum 24 is frequent. The cities include two official ports, Buenaventura and Tumaco, that are separated geographically 25 but connected by frequent marine traffic. The fraction of highly-related sample pairs (whose classification 26 accounts for uncertainty) was greater within cities versus between. However, based on both the fraction 27 of highly-related sample pairs and on a threshold-free approach (Wasserstein distances between parasite 28 populations) connectivity between Buenaventura and Tumaco was disproportionally high. Buenaventura- 29Tumaco connectivity was consistent with three separate transmission events involving parasites from five 30 different clonal components (groups of statistically indistinguishable parasites identified under a graph theo-31 retic framework). To conclude, P. falciparum population connectivity on the Colombian-Pacific coast abides 32 by accessibility not isolation-by-distance, potentially implicating marine traffic in malaria transmission with 33 opportunities for targeted intervention. Further investigations are required to test this and alternative hy-34 potheses. For the first time in malaria epidemiology, we account for uncertainty around estimated relatedness 35 (an important consideration for future studies that plan to use genotype versus whole genome sequence data 36 to estimate IBD-based relatedness); we also use a threshold-free approach to compare parasite populations, 37 and identify clonal components in a statistically principled manner. The approaches we employ could be 38 adapted to other recombining organisms with mixed mating systems, thus have broad relevance. 39 1 In many research fields genetic data are used to help characterise connectivity between geographically dis-41 parate biological populations, with numerous applications in conservation, agriculture, and public health. 42Patterns of genetic similarity between pathogen populations help us understand how the disease spreads. 43 Patterns of relatedness (a measure of genetic similarity) between malaria parasites in different human pop-44 ulations, for instance, help characterise the connectivity between them, thus guide the design of targeted 45 public health interventions [1]. 46 Several methods are employed to measure genetic similarity and thus characterise connectivity. Phylo-47 genetic methods, in which genetic distances between individuals are measured in unit...

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Spatial distributions of Anopheles species in relation to malaria incidence at 70 localities in the highly endemic Northwest and South Pacific coast regions of Colombia

Cited by 44 publications

References 47 publications

Ookinete-Specific Genes and 18S SSU rRNA Evidenced in Plasmodium vivax Selection and Adaptation by Sympatric Vectors

Ookinete-Specific Genes and 18S SSU rRNA Evidenced in Plasmodium vivax Selection and Adaptation by Sympatric Vectors

Entomological characterization of malaria in northern Colombia through vector and parasite species identification, and analyses of spatial distribution and infection rates

Identity-by-descent relatedness estimates with uncertainty characterise departure from isolation-by-distance betweenPlasmodium falciparumpopulations on the Colombian-Pacific coast

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