Spatial distributions of electric field, temperature, and pH generated by multiple electrode arrays

Abstract

Electrochemical therapy is used for cancer and its application is simple, safe, effective and induces minimal adverse effects to the body. It is not accepted as one more oncospecific therapy, among other reasons due to its lack of standardization. Therefore, the scientific problem of this research is that an electrode arrangement is not defined that maximizes tissue damage in the tumor with minimal damage to surrounding healthy tissue that allows its optimization for therapeutic planning and personalized therapy. The objective of the study is to simulate and compare the spatial distributions of the electric potential, electric field, temperature and tissue damage and pH generated by multiple pairs of electrodes that maximize the destruction of the tumor volume. It is concluded that the results suggest that multi-pair electrode configurations may be more effective for the treatment of large (diameter> 8 cm) and deep solid tumors.