2023
DOI: 10.1101/2023.07.18.548880
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Spatial Dynamic Subspaces Encode Sex-Specific Schizophrenia Disruptions in Transient Network Overlap and its Links to Genetic Risk

Abstract: Background: Recent advances in resting-state fMRI allow us to study spatial dynamics, the phenomenon of brain networks spatially evolving over time. However, most dynamic studies still use subject-specific, spatially-static nodes. As recent studies have demonstrated, incorporating time-resolved spatial properties is crucial for precise functional connectivity estimation and gaining unique insights into brain function. Nevertheless, estimating time-resolved networks poses challenges due to the low signal-to-noi… Show more

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“…In contrast to previous work conducted in patients with SCZ 26,100 , healthy adults [101][102][103] , and a large sample of individuals across the psychosis spectrum from childhood to adulthood 104 , here we did not find associations between SCZ PGS and resting-state FC, nor any other PGS, in participants of EUR ancestry.…”
Section: Discussioncontrasting
confidence: 99%
“…In contrast to previous work conducted in patients with SCZ 26,100 , healthy adults [101][102][103] , and a large sample of individuals across the psychosis spectrum from childhood to adulthood 104 , here we did not find associations between SCZ PGS and resting-state FC, nor any other PGS, in participants of EUR ancestry.…”
Section: Discussioncontrasting
confidence: 99%