The global dynamics of a nonlocal predator–prey model with mutation are investigated in this paper. First, by building a new comparison principle and constructing monotone iterative sequences, we give the existence of the solution for the corresponding initial boundary value problem. Then the uniqueness and uniformly boundedness of the solution are established by using the fundamental solution and quasi-fundamental solution of the heat equation, Grönwall’s inequality and auxiliary functions. Finally, under the truncation function method, we discuss the asymptotic behavior of the solution. It is worth mentioning that the asymptotic behavior here is different from the conclusion of the classical model and we use more refined analysis and estimation in the research process.