Spatial engineering of single-atom Fe adjacent to Cu-assisted nanozymes for biomimetic O2 activation

Wang, Ying; Paidi, Vinod K.; Wang, Weizhen; Wang, Yong; Jia, Guangri; Yan, Tingyu; Cui, Xiaoqiang; Cai, Songhua; Zhao, Jingxiang; Lee, Kug-Seung; Lee, Lawrence Yoon Suk; Wong, Kwok-Yin

doi:10.1038/s41467-024-46528-w

Cited by 16 publications

(1 citation statement)

References 70 publications

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“…Further investigation of this mechanism could explain how a single atom and its encompassing support material perform as one, providing this new design paradigm for catalysts . Interpretation of SANs’ degradation is the way to develop novel materials ready to withstand harsh environments.…”

Section: Opportunitiesmentioning

confidence: 99%

Unleashing the Potential of Single-Atom Nanozymes: Catalysts for the Future

Hamed,

Fung,

2024

ACS Sens.

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Single-atom nanozymes (SANs) have become a breakthrough in atomically precise catalysis, which relies on the catalytic active site formed by the single-atom itself. From this angle, SANs and their advantages compared to natural enzymes as well as spaces for their application are emphasized. The SANs have outstanding control over their catalytic activities; this is compared with bulk materials and natural enzymes. The structure of the SANs has very promising potential for the next generation of biosensing and biomedical devices and environmental remediation. Although their capabilities are high, difficulties still arise. The specificity, scalability, biosafety, and catalysis mechanisms raise additional issues that require further research. We build up a vision of the perspectives of the better implementation of SANs, which are designed for diagnostic purposes, improving industrial technologies, and creating new sustainable technologies in the food processing industry. AI and machine learning systems may clarify the structure−performance relationship of SANs for improved material and process selectivity. The future of SANs is very promising, and by addressing these challenges and leveraging advancements in artificial intelligence and materials science, SANs have the potential to become powerful tools for a sustainable future.

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Section: Opportunitiesmentioning

confidence: 99%

Unleashing the Potential of Single-Atom Nanozymes: Catalysts for the Future

Hamed,

Fung,

2024

ACS Sens.

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Atomic Interface Engineering‐Mediated Metallene Nanozyme Boosts Efficient Photothermal Catalytic Tumor‐Specific Therapy

Wu,

Jiao,

Liu

et al. 2024

Adv Funct Materials

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Tumor microenvironment (TME)‐responsive nanozymes‐based catalytic therapy shows great potential in combating malignant tumor. However, their biological application still suffers from deficient catalytic activity. Herein, the MoOx‐Rh metallene nanozyme demonstrates highly efficient multiple enzymatic catalytic activities, where MoOx species atomically dispersed on Rh metallene surface. The resulting structures enable MoOx‐Rh metallene with maximally exposed active oxide‐metallene interface and more atoms sites around interface can be well finely regulated. Results of experiment and density functional theory (DFT) simulations support the notion that atomic interface structure facilitates multiple enzyme‐like reactions. As a TME‐responsive nanozyme, MoOx‐Rh metallene exhibits remarkable therapeutic effect of tumor due to intrinsic near‐infrared photothermal effect and laser‐enhanced multiple enzymatic catalytic activities. This study illustrates the great promise of atomic interface engineering strategy in tumor catalytic therapy.

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Electron‐Deficient Effect Modulates Catalase‐Like Activity of Iron‐Nitrogen‐Carbon Nanozymes for Inflammatory Wound Therapy

Chen,

Guan,

Tan

et al. 2024

Adv Funct Materials

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Dual‐metal atom nanozymes (DANs) are frontier nanocatalysts that mimic natural enzymes to regulate the level of reactive oxygen species (ROS) in pathological tissue. However, the construction of DANs is mostly based on trial‐and‐error strategy rather than rational design due to their ambiguous catalytic mechanism. Herein, a promising strategy to construct highly efficient FeZn‐NC DANs by “electron‐deficient effect” for ROS scavenging is proposed. Redox‐inert Zn‐N4 sites and axial N atom induce electron‐deficient Fe sites based on different electronegativity to accelerate catalase (CAT)‐like reaction. Besides, FeZn‐NC mimics superoxide dismutase (SOD) relying on the cyano‐group conjugated with the π‐system in the carbon carrier. Enhanced CAT‐like activity from Fe sites and SOD‐like activity from carbon carriers enabled FeZn‐NC more effective in mitigating cellular damage and inducing the phenotypic transformation of macrophages in acute inflammatory wounds. This work establishes more precise structure‐activity relationships for CAT and SOD mimics and provides a paradigm for the treatment of inflammation‐related diseases by catalytic therapy.

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Spatial engineering of single-atom Fe adjacent to Cu-assisted nanozymes for biomimetic O2 activation

Cited by 16 publications

References 70 publications

Unleashing the Potential of Single-Atom Nanozymes: Catalysts for the Future

Unleashing the Potential of Single-Atom Nanozymes: Catalysts for the Future

Atomic Interface Engineering‐Mediated Metallene Nanozyme Boosts Efficient Photothermal Catalytic Tumor‐Specific Therapy

Electron‐Deficient Effect Modulates Catalase‐Like Activity of Iron‐Nitrogen‐Carbon Nanozymes for Inflammatory Wound Therapy

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