Spatial Immunology in Liver Metastases from Colorectal Carcinoma according to the Histologic Growth Pattern

Garcia-Vicién, Gemma; Mezheyeuski, Artur; Micke, Patrick; Ruiz, Núria; Ruffinelli, J.C.; Mils, Kristel; Bañuls, María; Molina, N.; Losa, Ferrán; Lladó, Laura; Mollevı́, David G.

doi:10.3390/cancers14030689

Cited by 7 publications

(5 citation statements)

References 30 publications

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“…Cancers, 2022 [91] The spaƟal distribuƟon of lymphocyƟc infiltrates in CRC liver metastases was explored in the context of the HGPs by mulƟplex immunofluorescence staining and digital image analysis in a cohort of 22 resected metastases without pre-surgery chemotherapy. HGPs were scored following the previous guidelines.…”

Section: Garcia-vicién Gmentioning

confidence: 99%

Histopathological growth patterns of liver metastasis: updated consensus guidelines for pattern scoring, perspectives and recent mechanistic insights

et al. 2022

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The first consensus guidelines for scoring the histopathological growth patterns (HGPs) of liver metastases were established in 2017. Since then, numerous studies have applied these guidelines, have further substantiated the potential clinical value of the HGPs in patients with liver metastases from various tumour types and are starting to shed light on the biology of the distinct HGPs. In the present guidelines, we give an overview of these studies, discuss novel strategies for predicting the HGPs of liver metastases, such as deep-learning algorithms for whole-slide histopathology images and medical imaging, and highlight liver metastasis animal models that exhibit features of the different HGPs. Based on a pooled analysis of large cohorts of patients with liver-metastatic colorectal cancer, we propose a new cut-off to categorise patients according to the HGPs. An up-to-date standard method for HGP assessment within liver metastases is also presented with the aim of incorporating HGPs into the decision-making processes surrounding the treatment of patients with liver-metastatic cancer. Finally, we propose hypotheses on the cellular and molecular mechanisms that drive the biology of the different HGPs, opening some exciting preclinical and clinical research perspectives.

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Section: Garcia-vicién Gmentioning

confidence: 99%

Histopathological growth patterns of liver metastasis: updated consensus guidelines for pattern scoring, perspectives and recent mechanistic insights

et al. 2022

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“…Last year, G. Garcia-Vicién et al mentioned an immunosuppressive microenvironment in MHCCR with ndHGP and an antitumor immune microenvironment in MHCCR with dHGP, a fact that reinforces the better prognosis associated with encapsulating metastases [190].…”

Section: After Crclm Resection-the Role Of Histopathological Growth P...mentioning

confidence: 95%

Colorectal Cancer Liver Metastasis—State-of-the-Art and Future Perspectives

Ruivo,

Oliveira,

Silva-Vaz

et al. 2023

Gastrointestinal Disorders

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The current management of colorectal cancer liver metastasis (CRCLM) patients involves a multidisciplinary approach, with surgical resection remaining the primary curative option. The advances in liver surgery have improved outcomes, enabling more patients to undergo surgery successfully. In addition, the development of imaging software has improved the preoperative planning and patient selection for surgery and other interventions. Systemic therapies, such as targeted therapies and immunotherapies, have enhanced the chances of complete resection. Targeted agents, in combination with chemotherapy, have shown efficacy in downstaging tumors and increasing resectability. The algorithm approach for these patients continues to evolve, driven by a deeper understanding of the underlying biology. Personalized medicine, guided by molecular profiling and the potential of liquid biopsies in this field, may lead to more tailored treatment strategies. A greater understanding of the immune microenvironment in CRLM may unlock the potential for immune checkpoint inhibitors and novel immunotherapies to become more prominent in the treatment landscape. This review explores the current state-of-the-art treatment of CRCLM and discusses promising future perspectives.

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“…Garcia-Vicién G Cancers 2022 89 The spatial distribution of lymphocytic infiltrates in CRC liver metastases was explored in the context of the HGPs by multiplex immunofluorescence staining and digital image analysis in a cohort of 22 resected metastases without pre-surgery chemotherapy. HGPs were scored following the previous guidelines.…”

Section: Colorectal Cancermentioning

confidence: 99%

Histopathological growth patterns of liver metastasis: updated consensus guidelines for pattern scoring, perspectives, and recent mechanistic insights

Latacz

Höppener

Bohlok

et al. 2022

Preprint

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The first consensus guidelines for scoring the histopathological growth patterns (HGPs) of liver metastases were established in 2017. Since then, numerous studies have applied these guidelines, have further substantiated the potential clinical value of the HGPs in patients with liver metastases from various tumour types and are starting to shed light on the biology of the distinct HGPs. In the present guidelines, we give an overview of these studies, discuss novel strategies for predicting the HGPs of liver metastases, such as deep learning algorithms for whole slide histopathology images and medical imaging, and highlight liver metastasis animal models that exhibit features of the different HGPs. Based on a pooled analysis of large cohorts of patients with liver-metastatic colorectal cancer, we propose a new cut-off to categorise patients according to the HGPs. An up-to-date standard method for HGP assessment within liver metastases is also presented with the aim of incorporating HGPs into the decision-making processes surrounding the treatment of patients with liver metastatic cancer. Finally, we propose hypotheses on the cellular and molecular mechanisms that drive the biology of the different HGPs, opening some exciting pre-clinical and clinical research perspectives.

show abstract

Spatial Immunology in Liver Metastases from Colorectal Carcinoma according to the Histologic Growth Pattern

Cited by 7 publications

References 30 publications

Histopathological growth patterns of liver metastasis: updated consensus guidelines for pattern scoring, perspectives and recent mechanistic insights

Histopathological growth patterns of liver metastasis: updated consensus guidelines for pattern scoring, perspectives and recent mechanistic insights

Colorectal Cancer Liver Metastasis—State-of-the-Art and Future Perspectives

Histopathological growth patterns of liver metastasis: updated consensus guidelines for pattern scoring, perspectives, and recent mechanistic insights

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