Spatial landscape of malignant pleural and peritoneal mesothelioma tumor immune microenvironment
Xiaojun Ma,
David Lembersky,
Elena S Kim
et al.
Abstract:Immunotherapies have shown modest clinical benefit thus far for malignant mesothelioma (MM). A deeper understanding of immune cell spatial distribution within the tumor immune microenvironment (TIME) is needed to identify interactions between tumor and different immune cell types that might impact the effectiveness of potential immunotherapies. We performed multiplex immunofluorescence (mIF) using tissue microarrays (TMAs, n=3) of samples from patients with malignant peritoneal (n=25) and pleural (n=88) mesoth… Show more
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