Spatial memory extinction: A c-Fos protein mapping study

Méndez-Couz, Marta; Conejo, Nélida M.; Vallejo, Guillermo; Árias, Jorge L.

doi:10.1016/j.bbr.2013.11.032

Cited by 21 publications

(47 citation statements)

References 74 publications

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“…In addition, the mammillary bodies and the medial prefrontal cortex have been largely related with spatial navigation [17][18][19] and memory extinction processes [20,21]. In particular, we reported a key role of the prefrontal cortex at late stages of spatial learning acquisition [19] that was later found at late phases of the extinction task [14].…”

Section: Introductionmentioning

confidence: 94%

“…Following the extinction protocol by [30] and previously explained in [14], animals had four extinction sessions the day after the learning retention probe. Each session consisted in four single non-reinforced trials in which no platform was available in the maze, of 60 s each, making a total of 16 trials.…”

Section: Extinction Protocolmentioning

confidence: 99%

“…The water temperature was kept at 20 ± 1 • C during the whole testing period. The pool was surrounded by numerous visual cues as explained in previous articles [14,27]. Each trial was recorded and later analyzed using a computerized video-tracking system (Ethovision Pro, Noldus Information Technologies, Wageningen, The Netherlands).…”

Section: Behavioral Proceduresmentioning

confidence: 99%

“…The extinction of spatial learning evaluated in the Morris water maze has been studied at a behavioral level [3,4] and used in a despairand depression-like model [2,[11][12][13]. Recently, we have reported results on late stages of spatial learning memory extinction [14], in which the infralimbic and prelimbic areas of the medial prefrontal cortex, together with the lateral mammillary nucleus and the amygdala, showed changes in c-Fos protein expression following the execution of extinction task.…”

Section: Introductionmentioning

confidence: 97%

See 3 more Smart Citations

Brain functional network changes following Prelimbic area inactivation in a spatial memory extinction task

Méndez-Couz

Conejo

Vallejo

et al. 2015

Behavioural Brain Research

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Section: Introductionmentioning

confidence: 94%

Section: Extinction Protocolmentioning

confidence: 99%

Section: Behavioral Proceduresmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

See 2 more Smart Citations

Brain functional network changes following Prelimbic area inactivation in a spatial memory extinction task

Méndez-Couz

Conejo

Vallejo

et al. 2015

Behavioural Brain Research

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“…Diversas demostraciones de recuperación espontánea de la memoria espacial con animales humanos (Luna & Martínez, 2015) y no humanos (Lattal et al, 2003;Leising, Wong & Blaisdell, 2015;Prados, Manteiga & Sansa, 2003) sugieren la participación del aprendizaje asociativo en la extinción de la memoria espacial. Sin embargo, existe también evidencia de la ausencia de este efecto (Méndez-Couz, Conejo, Vallejo & Arias, 2014;Rossato, Bevilaqua, Medina, Izquierdo & Cammarota, 2006), lo cual es consistente con posturas no asociativas de la adquisición y extinción de la memoria espacial (Burgess, Jackson, Hartley & O'Keefe, 2000;Foster, Morris & Dayan, 2000;O'Keefe & Nadel, 1978). No es del todo claro si dicha controversia obedece al proceso de aprendizaje mismo (i.e., asociativo vs. no asociativo) o debido a aspectos metodológicos propios a los estudios conducidos (para una discusión ver Luna & Martínez, 2015).…”

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Extinción y renovación de la memoria espacial en humanos

et al. 2017

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RESUMENParticipantes humanos fueron entrenados en un laberinto virtual de agua para localizar en dos fases sucesivas una plataforma cuya ubicación fue específica a la fase vigente. Posteriormente realizaron una prueba sin plataforma. El Grupo ABA realizó la primera fase y la prueba en un contexto A, y la segunda fase en un contexto B. El Grupo ABB realizó la primera fase en el contexto A, y la segunda fase y la prueba en el contexto B. Ambos grupos localizaron la plataforma en cada fase. Durante la prueba, la última ubicación de la plataforma fue preferida por el Grupo ABB, mientras que la primera ubicación fue preferida por el Grupo ABA. Estos resultados indican renovación de la memoria espacial en humanos.Palabras clave aprendizaje asociativo; laberinto virtual de agua; preferencia espacial; extinción; efectos de recuperación. ABSTRACTHuman participants were trained in a virtual water maze throughout two immediate phases, in order to locate a platform which particular location was specific to each phase. Afterwards, a trial without the platform was conducted.The ABA group experienced phase 1 and the test trial in Context A, while the second phase occurred in Context B. The ABB group received the first phase in Context A and the phase 2 and test trial training in Context B. Both groups had to locate the platform in each phase. During the test trial, the last platform location was preferred by the ABB group but the first platform location was preferred by the group ABA. These results suggest renewal of spatial memory in humans.

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Spatial memory extinction differentially affects dorsal and ventral hippocampal metabolic activity and associated functional brain networks

et al. 2016

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Previous studies showed the involvement of brain regions associated with both spatial learning and associative learning in spatial memory extinction, although the specific role of the dorsal and ventral hippocampus and the extended hippocampal system including the mammillary body in the process is still controversial. The present study aimed to identify the involvement of the dorsal and ventral hippocampus, together with cortical regions, the amygdaloid nuclei, and the mammillary bodies in the extinction of a spatial memory task. To address these issues, quantitative cytochrome c oxidase histochemistry was applied as a metabolic brain mapping method. Rats were trained in a reference memory task using the Morris water maze, followed by an extinction procedure of the previously acquired memory task. Results show that rats learned successfully the spatial memory task as shown by the progressive decrease in measured latencies to reach the escape platform and the results obtained in the probe test. Spatial memory was subsequently extinguished as shown by the descending preference for the previously reinforced location. A control naïve group was added to ensure that brain metabolic changes were specifically related with performance in the spatial memory extinction task. Extinction of the original spatial learning task significantly modified the metabolic activity in the dorsal and ventral hippocampus, the amygdala and the mammillary bodies. Moreover, the ventral hippocampus, the lateral mammillary body and the retrosplenial cortex were differentially recruited in the spatial memory extinction task, as shown by group differences in brain metabolic networks. These findings provide new insights on the brain regions and functional brain networks underlying spatial memory, and specifically spatial memory extinction. © 2016 Wiley Periodicals, Inc.

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Spatial memory extinction: A c-Fos protein mapping study

Cited by 21 publications

References 74 publications

Brain functional network changes following Prelimbic area inactivation in a spatial memory extinction task

Brain functional network changes following Prelimbic area inactivation in a spatial memory extinction task

Extinción y renovación de la memoria espacial en humanos

Spatial memory extinction differentially affects dorsal and ventral hippocampal metabolic activity and associated functional brain networks

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