2005
DOI: 10.1161/01.res.0000172544.56818.54
|View full text |Cite
|
Sign up to set email alerts
|

Spatial Nonuniformity of Excitation–Contraction Coupling Causes Arrhythmogenic Ca 2+ Waves in Rat Cardiac Muscle

Abstract: Abstract-Ca2ϩ waves underlying triggered propagated contractions (TPCs) are initiated in damaged regions in cardiac muscle and cause arrhythmias. We studied Ca 2ϩ waves underlying TPCs in rat cardiac trabeculae under experimental conditions that simulate the functional nonuniformity caused by local mechanical or ischemic local damage of myocardium. A mechanical discontinuity along the trabeculae was created by exposing the preparation to a small jet of solution with a composition that reduces excitation-contra… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2

Citation Types

6
82
0

Year Published

2006
2006
2023
2023

Publication Types

Select...
6
2

Relationship

2
6

Authors

Journals

citations
Cited by 60 publications
(88 citation statements)
references
References 43 publications
6
82
0
Order By: Relevance
“…Several of these simulations have neglected or greatly simplified Ca 2ϩ handling to address issues of scale. This can be valid but carries the risk of overlooking the potential importance of Ca 2ϩ homeostasis in arrhythmogenesis (1,67,72,77). As the field progresses, one important issue that will need to be addressed is what aspects of cellular and molecular behavior must be preserved and integrated on moving from cellular to organ function.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Several of these simulations have neglected or greatly simplified Ca 2ϩ handling to address issues of scale. This can be valid but carries the risk of overlooking the potential importance of Ca 2ϩ homeostasis in arrhythmogenesis (1,67,72,77). As the field progresses, one important issue that will need to be addressed is what aspects of cellular and molecular behavior must be preserved and integrated on moving from cellular to organ function.…”
Section: Discussionmentioning
confidence: 99%
“…There are at least two important general classes of behavior during repolarization that have a strong link to arrhythmogenic behavior in all mammalian hearts. Broadly, these include altered Ca 2ϩ homeostasis and changes in dispersion, or heterogeneity, of repolarization (2,7,44,54,60,72). Recently, several well-developed and computationally efficient Ca 2ϩ handling models have been published (see, for example, Refs.…”
Section: Discussionmentioning
confidence: 99%
“…In the myocardium with non-uniform contraction, regional differences in contractile strength may cause paradoxical stretching of the impaired muscle by contractions of the more viable neighboring muscle. 3 During the relaxation of the more viable muscle, the paradoxical shortening of the impaired muscle dissociates Ca 2+ from the myofilaments and then initiates Ca 2+ waves. 3 These Ca 2+ waves cause delayed afterdepolarizations (DADs) through the activation of Ca 2+ -activated transient inward currents across the sarcolemma, and their propagation features such as velocity and amplitude are deeply involved with the formation of DADs.…”
mentioning
confidence: 99%
“…3 During the relaxation of the more viable muscle, the paradoxical shortening of the impaired muscle dissociates Ca 2+ from the myofilaments and then initiates Ca 2+ waves. 3 These Ca 2+ waves cause delayed afterdepolarizations (DADs) through the activation of Ca 2+ -activated transient inward currents across the sarcolemma, and their propagation features such as velocity and amplitude are deeply involved with the formation of DADs. 4 Because DADs cause arrhythmias associated with catecholamine excess, 5 heart failure, 6 and mutations of the ryanodine receptor or calsequestrin…”
mentioning
confidence: 99%
“…7 Such diseased hearts not only exhibit an increase in diastolic intracellular Ca 2+ ([Ca 2+ ]i), 8 which causes spontaneous Ca 2+ release from the sarcoplasmic reticulum (SR), 9,10 but also exhibit nonuniform muscle contraction, 11,12 which causes Ca 2+ dissociation from the myofilaments within the border zone between contracting and stretched regions during the relaxation phase. 10,13, 14 Both the Ca 2+ released from the SR and that dissociated from the myofilaments can induce Ca 2+ waves, which propagate along the myocardium by the mechanism of Ca 2+ -induced Ca 2+ release from the SR. 15 Since the velocity and amplitude of Ca 2+ waves determine the formation of DADs 16 (ie, arrhythmogenesis principally through the activation of the Na + -Ca 2+ exchange (NCX) current 16,17 ), it is still important to investigate the propagation features of the Ca 2+ waves.…”
mentioning
confidence: 99%