Spatial Pain Propagation Over Time Following Painful Glutamate Activation of Latent Myofascial Trigger Points in Humans

Wang, Chao; Ge, Hong-You; Ibarra, José Miota; Yue, Shouwei; Madeleine, Pascal; Arendt-Nielsen, Lars

doi:10.1016/j.jpain.2012.03.001

Cited by 21 publications

(13 citation statements)

References 48 publications

(41 reference statements)

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“… 15 Furthermore, a topographical pressure pain sensitivity map of the wrist extensor muscles has also been applied in an experimentally induced pain study in which a glutamate injection into latent TrPs was reported to induce an early occurrence of a locally enlarged area of pressure hyperalgesia associated with spreading central sensitization. 36 …”

Section: Studies Reporting Topographical Pressure Pain Mapsmentioning

confidence: 99%

Spotlight on topographical pressure pain sensitivity maps: a review

Alburquerque‐Sendín¹,

Madeleine²,

Fernández‐de‐las‐Peñas³

et al. 2018

JPR

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Mechanical hyperalgesia defined as decreased pressure pain thresholds (PPTs) is commonly associated with pain. In this narrative review, we report the current state of the art within topographical pressure sensitivity maps. Such maps are based on multiple PPT assessments. The PPTs are assessed by an a priori defined grid with special focus on both spatial and temporal summation issues. The grid covers the muscle or the body region of interest using absolute or relative values determined from anatomical landmarks or anthropometric values. The collected PPTs are interpolated by Shepard or Franke and Nielson interpolation methods to create topographical pressure sensitivity maps. This new imaging technique has proven to be valuable in various disciplines including exercise physiology, neurology, physical therapy, occupational medicine, oncology, orthopedics, and sport sciences. The reviewed papers have targeted different body regions like the scalp, low back, neck–shoulder, and upper and lower extremities. The maps have delineated spatial heterogeneity in the pressure pain sensitivity underlining the different extents of pressure pain hyperalgesia in both experimentally induced and disease-associated pain conditions. Furthermore, various intervention studies have proven the utility of topographical pressure pain sensitivity maps. Topographical pressure pain sensitivity maps have contributed to revealing the efficacy of therapeutic, ergonomic, or training interventions that aim at reducing pain.

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Section: Studies Reporting Topographical Pressure Pain Mapsmentioning

confidence: 99%

Spotlight on topographical pressure pain sensitivity maps: a review

Alburquerque‐Sendín¹,

Madeleine²,

Fernández‐de‐las‐Peñas³

et al. 2018

JPR

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“…In addition, the absence of changes in the PPT in the left trapezius and infraspinatus seems to be due to the fact that the neurotransmitter did not affect the other side of the stimulus applied on the basis of the mid-sagittal plane [21]. Generally, the pain stimulation due to the repeated pressure threshold measurement at the same site is transmitted, resulting in peripheral sensitization and a decrease in the PPT [22,23]. However, this study did not show a tendency for the PPT to decrease significantly in all muscles, so it seems as though the peripheral sensitization did not appear.…”

Section: Discussionmentioning

confidence: 99%

Effects of mechanical intervention on cutaneous sensory change and pressure pain threshold in the same spinal segment of myofascial pain

Kim

Lee

2019

PTRS

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The purpose of this study was to identify whether cutaneous sensory (CS) changes induced by mechanical intervention (MI) increases the trigger point threshold of the same spinal segment as well as to investigate the relationship between the amounts of change in CS pressure pain thresholds (PPT). Design: Randomized controlled trial. Methods: Thirty-nine persons with myofacial pain (MFP) were recruited in this experiment. The subjects consisted of 20 men and 19 women (age 20-39). MI was applied on the subjects using the Graston technique for 5 minutes to induce CS changes. The CS changes were measured with sensory tests by using the Von Frey Filament, and PPT changes were estimated by using the pressure threshold meter. For the observation of sensory and PPT changes with time, the test was conducted for 15 minutes including a pre, post, and after intervention session. Results: CS threshold increased significantly when MI was applied (p<0.001). On the same spinal segment, changes in the right infraspinatus PPT was observed (p<0.001) but the PPT changes in other muscles were not significantly different. Furthermore, the control group CS and PPT were not significantly different. In addition, regression analysis showed that the CS changes have a larger impact on PPT in the same spinal segment (p<0.001). Conclusions: CS changes induced by MI make to change PPT on the same spinal segment. In other words, it is possible to identify PPT changes following CS changes except for the muscle which belongs to a different spinal segment. Therefore, application of MI is necessary for the CS changes in the same spinal segment. Furthermore, it can be useful in the clinical fields as a method of providing pain control and increasing the PPT.

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“…19 Glutamate injection into latent myofascial trigger points in humans produces greater pain intensity, greater area of referred pain, and increased mechanical hyperalgesia than injection into nontrigger point control sites. 20 These results suggest that exogenous glutamate can be noxious in experimental animals and humans.…”

Section: Peripheral Glutamate Induces Craniofacial Muscle Pain and Hymentioning

confidence: 94%

Peripheral glutamate receptor and transient receptor potential channel mechanisms of craniofacial muscle pain

Chung

2020

Mol Pain

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Temporomandibular joint disorder is a common chronic craniofacial pain condition, often involving persistent, widespread craniofacial muscle pain. Although the etiology of chronic muscle pain is not well known, sufficient clinical and preclinical information supports a contribution of trigeminal nociceptors to craniofacial muscle pain processing under various experimental and pathological conditions. Here, we review cellular and molecular mechanisms underlying sensitization of muscle nociceptive afferents. In particular, we summarize findings on pronociceptive roles of peripheral glutamate in humans, and we discuss mechanistic contributions of glutamate receptors, including N-methyl-D-aspartate receptors and metabotropic glutamate receptors, which have considerably increased our understanding of peripheral mechanisms of craniofacial muscle pain. Several members of the transient receptor potential (TRP) family, such as transient receptor potential vanilloid 1 (TRPV1) and transient receptor potential ankyrin 1, also play essential roles in the development of spontaneous pain and mechanical hypersensitivity in craniofacial muscles. Furthermore, glutamate receptors and TRP channels functionally and bi-directionally interact to modulate trigeminal nociceptors. Activation of glutamate receptors invokes protein kinase C, which leads to the phosphorylation of TRPV1. Sensitization of TRPV1 by inflammatory mediators and glutamate receptors in combination with endogenous ligands contributes to masseter hyperalgesia. The distinct intracellular signaling pathways through which both receptor systems engage and specific molecular regions of TRPV1 are offered as novel targets for the development of mechanism-based treatment strategies for myogenous craniofacial pain conditions.

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Spatial Pain Propagation Over Time Following Painful Glutamate Activation of Latent Myofascial Trigger Points in Humans

Cited by 21 publications

References 48 publications

Spotlight on topographical pressure pain sensitivity maps: a review

Spotlight on topographical pressure pain sensitivity maps: a review

Effects of mechanical intervention on cutaneous sensory change and pressure pain threshold in the same spinal segment of myofascial pain

Peripheral glutamate receptor and transient receptor potential channel mechanisms of craniofacial muscle pain

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