Spatial-Temporal Patterns and Inflammatory Factors of Bone Matrix Remodeling

Wang, Jiechen; Guo, Fengyuan; Chen, Guangjin; Sun, Jiwei; Tang, Qingming; Chen, Lili

doi:10.1155/2021/4307961

Cited by 5 publications

(9 citation statements)

References 131 publications

(192 reference statements)

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“…In particular, the transforming growth factor β signaling pathway has been considered a critical regulatory pathway in the extracellular matrix regulatory network. [ 45 ]…”

Section: Resultsmentioning

confidence: 99%

“…In particular, the transforming growth factor 𝛽 signaling pathway has been considered a critical regulatory pathway in the extracellular matrix regulatory network. [45] Osteogenic directional enrichment analysis was performed to further understand the osteogenesis-related processes regulated by BP. The results showed that BP mainly participated in extracellular matrix organization, extracellular structural organization, ossification, skeletal system morphology, renal system development, cartilage development, osteogenic differentiation of BM-SCs, and osteoblast differentiation (Figure 5F).…”

Section: Transcriptomic Mechanisms Of Signal Transduction and Regulat...mentioning

confidence: 99%

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Black Phosphorus Accelerates Bone Regeneration Based on Immunoregulation

Qiu,

Tulufu,

Tang

et al. 2023

Advanced Science

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A fundamental understanding of inflammation and tissue healing suggests that the precise regulation of the inflammatory phase, both in terms of location and timing, is crucial for bone regeneration. However, achieving the activation of early inflammation without causing chronic inflammation while facilitating quick inflammation regression to promote bone regeneration continues to pose challenges. This study reveals that black phosphorus (BP) accelerates bone regeneration by building an osteogenic immunological microenvironment. BP amplifies the acute pro‐inflammatory response and promotes the secretion of anti‐inflammatory factors to accelerate inflammation regression and tissue regeneration. Mechanistically, BP creates an osteoimmune‐friendly microenvironment by stimulating macrophages to express interleukin 33 (IL‐33), amplifying the inflammatory response at an early stage, and promoting the regression of inflammation. In addition, BP‐mediated IL‐33 expression directly promotes osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs), which further facilitates bone repair. To the knowledge, this is the first study to reveal the immunomodulatory potential of BP in bone regeneration through the regulation of both early‐stage inflammatory responses and later‐stage inflammation resolution, along with the associated molecular mechanisms. This discovery serves as a foundation for the clinical use of BP and is an efficient approach for managing the immune microenvironment during bone regeneration.

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“…In particular, the transforming growth factor β signaling pathway has been considered a critical regulatory pathway in the extracellular matrix regulatory network. [ 45 ]…”

Section: Resultsmentioning

confidence: 99%

Section: Transcriptomic Mechanisms Of Signal Transduction and Regulat...mentioning

confidence: 99%

Black Phosphorus Accelerates Bone Regeneration Based on Immunoregulation

Qiu,

Tulufu,

Tang

et al. 2023

Advanced Science

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“…Functional enrichment analysis of those up-regulated genes uncovered 40 significantly enriched biological processes (threshold P=0.01). These enriched biological processes encompassed skeletal system development (logP=-11.96), tissue remodeling including bone resorption, cell matrix assembly (logP=-10.37) [47,48], regulation of cell adhesion (logP=-8.44), regulation of MAPK cascade [49] (logP=-5.22) and autophagy in bone metabolism [50,51], which have been associated with bone formation and bone remodeling [19,[52][53][54] . Additional enriched biological progress included ossification (e.g., bone mineralization and endochondral ossification) [55], myeloid leukocyte differentiation (e.g., osteoclast differentiation and osteoclast development) [56,57], epithelial cell proliferation (e.g., angiogenesis) [58][59][60][61], inorganic ion homeostasis [62,63], regulation of hormone levels [64,65], negative regulation of response to external stimulus [57,66], Vitamin D receptor pathway [67][68][69], cell migration and chemotaxis [70] (Fig.…”

Section: Bone Homeostasis Related Biological Processes Were Up-regula...mentioning

confidence: 99%

Unraveling the Molecular Landscape of Congenital Pseudoarthrosis of the Tibia: Insights from a Comprehensive Analysis of 162 Probands

Zhu,

Li,

Zheng

et al. 2023

Preprint

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Congenital pseudarthrosis of the tibia (CPT, HP:0009736), commonly known as bowing of the tibia, is a rare congenital tibia malformation characterized by spontaneous tibial fractures and the difficulty of reunion after tibial fractures during early childhood, with a very low prevalence between 1/250,000 ~ 1/140,000. While 80% ~ 84% of CPT cases present with neurofibromatosis type 1, caused by the mutations in NF1, the underlying cause of CPT is still unclear. Considering the congenital nature and the low prevalence of CPT, we hypothesized that the rare genomic mutations may contribute to CPT. In this study, we conducted whole exome sequencing on 159 patients with CPT and full-length transcriptome sequencing on an additional 3 patients with CPT. The data analysis showed there were 179 significantly up-regulated genes which were enriched in 40 biological processes among which 21 biological processes hold their loss of function (LoF) excesses between 159 cases against 208 controls from 1000 Genomes Project. From those 21 biological processes with LoF excesses, there were 259 LoF-carried genes among which 40 genes with 56 LoF variations in 63 patients were enriched in osteoclast differentiation pathway (hsa04380) with its 3 directly regulated pathways including MAPK signaling pathway (hsa04010), calcium signaling pathway (hsa04020) and PI3K-Akt signaling pathway (hsa04151), as well as fluid shear stress and atherosclerosis pathway (hsa05418) while 12 patients carried 9 LoF variations in the NF1 gene. The rare LoF variations in these pathways accounted for ~39.6% of this CPT cohort. These findings shed light on the novel genetic mutations and molecular pathways involved in CPT, providing a new framework for understanding how the genetic variations regulate the biological processes in the pathology of CPT and indicating potential next directions to further elucidate the pathogenesis of CPT.

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“…When the expression of RORb was up-regulated in MC3T3-E1 cells, transcription of Runx2 and its target genes Ocn and osterix (Osx) were significantly inhibited (34). ( 2) Transforming growth factor b (TGF-b) and bone morphogenetic protein (BMP) control the formation of extracellular matrix (ECM) and provide a framework for bone mineral deposition (38). Studies have shown that overexpression of RORb upregulated the expression of these cytokines and then interfered with ECM synthesis, thereby inhibiting bone mineralization (36).…”

Section: Rorb In Osteoporosismentioning

confidence: 99%

The role of retinoic acid receptor-related orphan receptors in skeletal diseases

Zhang,

Ma,

Bao

et al. 2023

Front. Endocrinol.

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Bone homeostasis, depending on the balance between bone formation and bone resorption, is responsible for maintaining the proper structure and function of the skeletal system. As an important group of transcription factors, retinoic acid receptor-related orphan receptors (RORs) have been reported to play important roles in bone homeostasis by regulating the transcription of target genes in skeletal cells. On the other hand, the dysregulation of RORs often leads to various skeletal diseases such as osteoporosis, rheumatoid arthritis (RA), and osteoarthritis (OA). Herein, we summarized the roles and mechanisms of RORs in skeletal diseases, aiming to provide evidence for potential therapeutic strategies.

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Spatial-Temporal Patterns and Inflammatory Factors of Bone Matrix Remodeling

Cited by 5 publications

References 131 publications

Black Phosphorus Accelerates Bone Regeneration Based on Immunoregulation

Black Phosphorus Accelerates Bone Regeneration Based on Immunoregulation

Unraveling the Molecular Landscape of Congenital Pseudoarthrosis of the Tibia: Insights from a Comprehensive Analysis of 162 Probands

The role of retinoic acid receptor-related orphan receptors in skeletal diseases

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