Arid oasis ecosystems are susceptible and fragile ecosystems on Earth. Studying the interaction between deserts, oases, and impervious surfaces is an essential breakthrough for the harmonious and sustainable development of people and land in drylands. Based on gridded data such as land use and NDVI, this article analyzes the interaction characteristics between oases, deserts, and impervious surfaces in northern Egypt and examines their dynamics using modeling and geographic information mapping methods. The results show the following: In terms of the interaction between deserts and oases, the primary manifestation was the expansion of oases and the reduction of deserts. During the study period, the oases in the Nile Delta and Fayoum District increased significantly, with the area of oases in 2020 being 1.19 times the area in 2000, which shows a clear trend of advance of people and retreat of sand. The interaction between oases and impervious surfaces was mainly observed in the form of the spread of impervious surfaces on arable land into oases. During the study period, the area of impervious surfaces increased 2.32 times. The impervious surface expanded over 1903.70 km2 of arable land, accounting for 66.67% of the expanded area. The central phenomenon between the impervious surface and the desert was the encroachment of the covered area of the impervious surface into the desert, especially around the city of Cairo. Population growth and urbanization are the two central drivers between northern Egypt’s oases, deserts, and impervious surfaces. The need for increased food production due to population growth has forced oases to move deeper into the desert, and occupation of arable land due to urbanization has led to increasing pressure on arable land, creating a pressure-conducting dynamic mechanism. Finally, countermeasures for sustainable regional development are suggested.