Spatial Transcriptomics Identifies Expression Signatures Specific to Lacrimal Gland Adenoid Cystic Carcinoma Cells

Moeyersoms, Acadia Hanne Marlene; Gallo, Ryan A.; Zhang, Michelle G.; Stathias, Vasileios; Maeng, Michelle M; Owens, Dawn A.; Khzam, Rayan Abou; Sayegh, Yoseph; Maza, Carlos; Dubovy, Sander R.; Tse, David T.; Pelaez, Daniel

doi:10.3390/cancers15123211

Cited by 4 publications

(2 citation statements)

References 54 publications

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“…A denoid cystic carcinoma (ACC) is the most common malignant epithelial tumor of the lacrimal gland, accounting for 11% of cystic epithelial tumors and 1.6% of all orbital tumors [1][2] . ACC may involve extensive local infiltration, significant bone metastasis, and peripheral nerve infiltration [3] .…”

Section: Introductionmentioning

confidence: 99%

Treatment of lacrimal gland adenoid cystic carcinoma: a systematic review and Meta-analysis

Yan,

Wang,

et al. 2024

Int J Ophthalmol

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AIM: To evaluate lacrimal gland adenoid cystic carcinoma (LGACC) of prognosis in patients who underwent different treatment regimens. METHODS: We searched PubMed, EMBASE, and the Cochrane Library for studies done on the treatment of LGACC, between January 1987 and April 2022. A Meta-analysis was conducted to pool the 5-year overall survival rate (OR), and the 5-year recurrence rate (RR) and 5-year metastasis rate (MR) were assessed. RESULTS: The 30 studies involved 585 patients were included in the Meta-analysis. The pooled 5-year OR with surgery alone was 50%, the 5-year RR was 63%, and the 5-year MR was 34%. The pooled 5-year OR with surgery and adjuvant radiotherapy combined was 67% (95%CI 61%,73%), the 5-year RR was 41%, and the 5-year MR was 35%. The pooled 5-year OR with surgery and adjuvant chemoradiotherapy combined was 72% (95%CI 59%, 84%), the 5-year RR was 48%, and the 5-year MR was 36%. The pooled 5-year OR with surgery, intra-arterial cytoreductive chemotherapy, and adjuvant chemoradiotherapy combined was 78% (95%CI 68%, 89%), the 5-year RR was 15%, and the 5-year MR was 27%. CONCLUSION: Comprehensive treatment is more effective than surgery alone. Surgery combined with intra-arterial chemotherapy and adjuvant chemoradiotherapy seems to add value to the therapeutic effect of comprehensive treatment of LGACC but further high-quality research is required to validate this.

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Section: Introductionmentioning

confidence: 99%

Treatment of lacrimal gland adenoid cystic carcinoma: a systematic review and Meta-analysis

Yan,

Wang,

et al. 2024

Int J Ophthalmol

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“… 5 Due to the rarity of LGACC, accurate diagnosis, treatment, and management are challenging. 6 A fast and reliable intraoperative method to detect tumor margins, assisting in removal of involved tissues and sparing uninvolved areas, has always been a potentially ideal method. So, we report a patient with ACC arising in the LG with proptosis of the right orbit.…”

Section: Introductionmentioning

confidence: 99%

Intraoperative use of electrical impedance spectroscopy for adenoid cystic carcinoma of the lacrimal gland: A case report

Fattahi,

Zarafshani,

Abdolahad

et al. 2023

Clinical Case Reports

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Key Clinical MessageElectrical Impedimetric Tumor Detection System is a novel and promising tool for fast intraoperative tumor delineation and accurate safe margin detection in orbital tumors.AbstractAdenoid cystic carcinoma (ACC) is a rare malignant tumor of epithelial origin, typically arising from the salivary and lacrimal glands. ACC is notorious for recurrence and a high rate of morbidity and mortality despite therapy. We presented a 48‐year‐old male patient with lacrimal gland ACC of the right orbit who underwent radical tumor resection and adjuvant radiotherapy. We applied a new diagnostic method, the Electrical Impedimetric Tumor Detection System, during surgery and tested its performance to enhance the precision of tumor resection. Two months after surgery, he underwent external radiation of 58 Gy in 29 fractions. He showed no tumor recurrence or metastasis in the 1‐year follow‐up visits. ITDS showed a precision of tumor and margin detection consistent with histopathology results. This novel ITDS may be a reliable system for fast intraoperative tumor delineation and accurate, safe margin detection in orbital tumors.

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Circulating adenoid cystic carcinoma associated MYB transcripts enable rapid and sensitive detection of metastatic disease in blood liquid biopsies

Moeyersoms,

Knechtel,

Rong

et al. 2024

The Journal of Liquid Biopsy

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Spatial Transcriptomics Identifies Expression Signatures Specific to Lacrimal Gland Adenoid Cystic Carcinoma Cells

Cited by 4 publications

References 54 publications

Treatment of lacrimal gland adenoid cystic carcinoma: a systematic review and Meta-analysis

Treatment of lacrimal gland adenoid cystic carcinoma: a systematic review and Meta-analysis

Intraoperative use of electrical impedance spectroscopy for adenoid cystic carcinoma of the lacrimal gland: A case report

Circulating adenoid cystic carcinoma associated MYB transcripts enable rapid and sensitive detection of metastatic disease in blood liquid biopsies

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