Precision agricultural technologies, such as the use of spatial variability of soil properties, have been extensively studied for soybean cultivation. The objective of this study was to analyze the spatial variability of soil properties cultivated with soybean and to correlate the healthy vegetation (HV) spectral index with the bands B8A (classifying vegetation - 865 nm), B11 (measuring the moisture content of soil and vegetation - 1610 nm), B02 blue (useful for soil and vegetation discrimination - 490 nm). A sampling grid was installed for data collection in an area of 2,126.02 ha, with 270 regular points and 98 random points, totaling 368 points. For the soil, the contents of P (resin), K+, Ca2+, Mg2+, H+, Al3+, pH values, sum of bases (SB), cation exchange capacity (CEC), and base saturation were determined at a depth of 0.0 to 0.20 m. Most of the soil properties had exponential and spherical dependence. Clay percentages and Ca, Mg, and P contents had positive spatial correlation with the healthy vegetation spectral index (HV) while no spatial correlation was observed for pH, B, K, silt, sand, S, H+Al, Al, SB, and CEC. The sensor image used in this study in relation to HV showed good application for observing the spatial variability of the soil properties and soybean yield.