This paper constructs the innovative development model of cultural and tourism integration based on the digital development process of cultural and creative industries and the rural tourism industry under the background of informationization. Then, it analyzes the comprehensive development level, coupled and coordinated development characteristics, and regional differences of cultural and creative industries and rural tourism industries in the whole country and 7 regions by using the coupled and coordinated degree model. Finally, the effectiveness of the digital development model of cultural and tourism integration is analyzed through the multiple linear regression model, and the moderating effect of the digital development model of cultural and tourism integration on the regional service capacity, infrastructure, and economic development is explored in depth. The results show that for every 1 percentage point increase in the level of digitalized development of cultural and tourism integration, the employment in the regional tertiary industry increases by 1.5%, the level of infrastructure development increases by 1.6%, and the level of local economic development grows by 1.2%. This study enriches and improves the content framework of the research on the high-quality development of rural tourism and provides new analytical ideas for the research on the high-quality development of rural tourism and cultural and creative industries.