Spatially Confined Fabrication of Core–Shell Gold Nanocages@Mesoporous Silica for Near-Infrared Controlled Photothermal Drug Release

Abstract

In this work, we have successfully developed a novel multifunctional near-infrared (NIR)-stimulus controlled drug release system based on gold nanocages as photothermal cores, mesoporous silica shells as supporters to increase the anticancer drug loading and thermally responsive poly(N-isopropylacrylamide) (PNIPAM) as NIR-stimuli gatekeepers (Au-nanocage@mSiO2@ PNIPAM). The unique Au-nanocage@mSiO2 nanocarrier was elaborately fabricated by utilizing yolk-shell Ag-nanocube@mSiO2 nanostructure as a template by means of spatially confined galvanic replacement. The Au nanocage cores can effectively absorb and convert light to heat upon irradiation with a NIR laser, resulting in the collapse of the PNIPAM shell covering the exterior of mesoporous silica, and exposes the pores of mesoporous silica shell, realizing the triggered release of entrapped DOX drugs. The in vitro studies have clearly demonstrated the feasibility and advantage of the novel nanocarriers for remote-controlled drug release systems.

“Elastic” Property of Mesoporous Silica Shell: For Dynamic Surface Enhanced Raman Scattering Ability Monitoring of Growing Noble Metal Nanostructures via a Simplified Spatially Confined Growth Method

“…23 Spatially confined synthesis of core−shell gold nanocages@mSiO 2 by etching silver NP seeds has been reported for near-infrared controlled photothermal drug release. 24 Herein, we propose a systematic approach for dynamic SERS monitoring of metal NPs of changing morphology, inspired by a simplified spatially confined growth method using mSiO 2 -coated gold nanorod (AuNR) as a model seed. The permeability of mSiO 2 for both reactive species and Raman reporters not only induces the reaction but also simultaneously indicates the Raman enhancing ability of instant NP products.…”

Mesoporous silica nanoparticles for stimuli-responsive controlled drug delivery: advances, challenges, and outlook

“…When this device was irradiated with NIR laser (808 nm, 1.5 W/cm 2 ), the generated heat enables denaturing of the duplex oligonucleotides of the DNA strands opening the pores and allowing the drugs to diffuse out of the carrier. Yang et al 146 developed a novel multifunctional NIR-stimuluscontrolled drug-release system based on gold nanocages as photothermal cores, mesoporous silica shells as supporters to increase the anticancer drug loading, and thermo-responsive PNIPAM as NIR-stimulus gatekeepers (Au-nanocage@ mSiO 2 @PNIPAM). The Au nanocage cores can effectively absorb and convert light into heat upon irradiation with an NIR laser, thereby resulting in the collapse of the PNIPAM shell covering the surface of mesoporous silica and exposing the nanochannels outside, realizing the triggered release of entrapped DOX.…”

Recent Advances in Nanoparticle Shape and Composition Regulation Based on Galvanic Replacement for Cancer Treatment

“…Hollow nanocages exhibit fascinating characteristics, in that their localized surface plasmon resonances (LSPRs) shift to the near-infrared (NIR) wavelength region owing to the narrowing of the energy gap between the anti-symmetric anti-bonding resonance modes and the symmetric bonding resonance modes depending on shell thickness and diameter [109][110][111][112][113][114][115][116][117][118]. These high-extinction features in the NIR region induce strong exothermic phenomenon caused by the surface plasmon oscillation through laser irradiation in the corresponding wavelength range, which is often referred to as photothermal conversion [119][120][121][122][123][124][125][126][127][128][129][130][131][132][133]. In cancer treatment, photothermal conversion is highly efficient in killing cancer cells vulnerable to hyperthermia.…”