Spatio-seasonal distribution of &lt;i&gt;Anopheles gambiae sensu lato&lt;/i&gt; and dynamics of the Voltage gate sodium channel knock down resistance mutation (&lt;i&gt;Vgsc1014F&lt;/i&gt;) in the city of Lomé, Togo

Ahadji-Dabla, Koffi Mensah; Ngoagouni, Carine; Dery, B. Dominic; Ketoh, Guillaume Koffivi; Glitho, Isabelle Adolé

doi:10.4314/ijbcs.v13i3.36

Cited by 3 publications

(2 citation statements)

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“…gambiae s.l. aux pyréthrinoïdes, seuls insecticides utilisés pour l'imprégnation des moustiquaires est connue au Bénin et bien documentée (Aïkpon et al, 2014 ;Ahadji-dabla et al, 2019) Il apparaît important, au regard de la dynamique qui caractérise les populations d'organismes vivants, de s'intéresser à l'évolution biologique dans le temps et dans l'espace des espèces vectrices comme An. gambiae s.l.…”

Section: Introductionunclassified

Hétérogénéité génétique et résistance des vecteurs du paludisme (Anopheles gambiae s.l) aux insecticides en zone cotonnière au Benin

Aïkpon¹,

Missihoun²,

Lokossou³

et al. 2020

Int. J. Bio. Chem. Sci

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La résistance des vecteurs du paludisme aux insecticides utilisés dans la lutte anti vectorielle est un obstacle majeur pour les programmes nationaux de lutte contre le paludisme. La présente étude avait pour but d’évaluer la diversité génétique des populations de Anopheles gambiae et la résistance aux insecticides (mutation Kdr et Ace-1) en zone cotonnière au Bénin. Deux méthodes de capture ont été utilisées pour la collecte d’échantillon. La capture sur appât humain et la récolte de la faune résiduelle matinale par spray. La PCR SINE a permis de distinguer deux espèces jumelles et d’obtenir les différents génotypes pour les deux gènes. Deux espèces du complexe An. gambiae s.l ont été trouvées en sympatrie (Anopheles coluzzii et Anopheles gambiae). La résistance kdr et Ace-1 connaissent un flux saisonnier. L’allèle résistant du gène kdr est fixé dans la population de vecteurs (Fis>0). Par contre, un déficit de l’allèle résistant est noté au niveau du gène Ace-1 (Fis<0).Mots clés : Hétérogénéité, génétique, résistance, vecteur, paludisme. English Title: Genetic heterogeneity and resistance to insecticides in malaria vector Anopheles gambiae s.l in the cotton growing area in Benin Resistance of malaria vectors to insecticides used in vector control is a major threat for national malaria control programs. The purpose of this study was to assess the genetic diversity of Anopheles gambiae populations and resistance to insecticides (Kdr Ace-1 mutation) in the cotton growing area in Benin. Two samples methods were used for mosquito collection: Human Landing catch (HLC) and the residual fauna collection by spray. The SINE PCR allow to identify species the different genotypes resistance genes. Two species of the An. gambiae s.l complex have been found in sympatry (Anopheles coluzzii and Anopheles gambiae). kdr and Ace-1 resistance had seasonal variation trend. The kdr resistance allele is fixed in the vector population (Fis> 0). Moreover, a deficit of the Ace-1 resistance allele was observed (Fis <0). Keywords: Heterogeneity, genetic, resistance, vector, malaria.

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Section: Introductionunclassified

Hétérogénéité génétique et résistance des vecteurs du paludisme (Anopheles gambiae s.l) aux insecticides en zone cotonnière au Benin

Aïkpon¹,

Missihoun²,

Lokossou³

et al. 2020

Int. J. Bio. Chem. Sci

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“…Currently, water scarcity is a central concern for many cities. In Abidjan, with rapid population growth, urbanization and economic development (Ahadji-Dabla et al 2019), demand for water among populations is growing (Atta et al, 2013;Tia and Séka, 2015). The lack of water leads the inhabitants to save this precious resource (Kouakou et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Household water storage containers: Aedes aegypti larval breeding site and high risk of transmission of arboviruses in Abidjan, Côte d'Ivoire

Diakaridia¹,

Konan²,

Koné³

et al. 2022

Int. J. Bio. Chem. Sci

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Dengue 3 epidemic was declared in Abidjan in 2018. Vector control was directed towards management of breeding sites to reduce proliferation of mosquitoes. Thus, characterization was carried out through larval prospecting in 100 households in six communes of Abidjan in February and August (large and small dry season) of 2018, before and after mosquito control. 3,809 larval breeding sites were inventoried, including 2,289 before and 1,520 after (p-value > 0.05). 76% of sites (2,909), consisted of water storage (1,380) and abandoned containers (1,529). These two categories were most abundant in households (p-value <0.0001). Greatest number of storage containers were observed in Attécoubé (n = 312) and Abobo (n = 296). Abandoned containers were abundant in Port-Bouet (n = 416). Number of abandoned containers was reduced from 1,016 before to 513 after operation (p-value < 0.01). However, water storage containers have increased slightly. It went from 686 before operation to 694 after. Positive storage containers (255) were also the most numerous (53%). Their proportions were 151 (41%) and 104 (55%) before and after mosquito control. They were very productive in Aedes aegypti. Household water storage containers could lead to reconstitution, maintenance of mosquitoes and increased risk of arboviruses spread in Abidjan.

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Multiple Insecticide Resistance in Anopheles arabiensis Patton in Khartoum State, Sudan, with High Pyrethroid Resistance Associated with Knockdown Resistant (kdr) Gene

Korti,

Abuelmaali,

Ageep

et al. 2024

Int J Med Parasitol Epidemiol Sci

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Introduction: Insecticide resistance is one of the major challenges in vector control programs around the globe. This study investigated the insecticide resistance and kdr mutation in the Anopheles arabiensis malaria vector in Khartoum State, Sudan. Methods: Entomological cross-sectional surveys were carried out at four urban and suburban sites in Khartoum State. Four insecticides were tested for World Health Organization (WHO) susceptibility, and kdr frequencies were estimated using two allele-specific PCR assays. Results: WHO bioassay tests revealed that DDT, malathion, and permethrin showed high resistance in both urban and suburban sites. There is no significant difference in mortality rates between urban and suburban sites (P>0.05), with the exception of DDT, where mosquitoes from urban sites showed more susceptibility [64 (51.23-76.77)] than those from suburban areas [53.5 (69.73-95.27)]. In general, all populations from the four sites showed faster KDT50% to bendiocarb and permethrin than to malathion and DDT insecticides. Generalized linear model analysis revealed that insecticide type, site type, and their interaction were determinant factors in mortality rate. A high to moderate frequency of the West African kdr mutation (L1014F) was observed in urban and suburban sites, and the association between the presence of the kdr mutation and resistance phenotype was strong for permethrin and DDT (OR>7 in the allelic test). Conclusion: This study showed the susceptibility status of the malaria vector A. arabiensis to four insecticides belonging to different classes in urban and suburban sites. This provides important knowledge that helps vector surveillance and control programs. Additionally, more research is necessary to explore the impact of pyrethroid resistance, particularly in bednets, and other resistance mechanisms in this malaria vector.

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Spatio-seasonal distribution of <i>Anopheles gambiae sensu lato</i> and dynamics of the Voltage gate sodium channel knock down resistance mutation (<i>Vgsc1014F</i>) in the city of Lomé, Togo

Cited by 3 publications

References 46 publications

Hétérogénéité génétique et résistance des vecteurs du paludisme (Anopheles gambiae s.l) aux insecticides en zone cotonnière au Benin

Hétérogénéité génétique et résistance des vecteurs du paludisme (Anopheles gambiae s.l) aux insecticides en zone cotonnière au Benin

Household water storage containers: Aedes aegypti larval breeding site and high risk of transmission of arboviruses in Abidjan, Côte d'Ivoire

Multiple Insecticide Resistance in Anopheles arabiensis Patton in Khartoum State, Sudan, with High Pyrethroid Resistance Associated with Knockdown Resistant (kdr) Gene

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