2024
DOI: 10.1101/2024.11.10.622609
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Spatio-temporal dynamics of the fibrotic niche in cardiac repair

Andy Shing Fung Chan,
Joachim Greiner,
Tomas Brennan
et al.

Abstract: The heart is one of the least regenerative organs in humans, and ischemic heart disease is the leading cause of death worldwide. Understanding the cellular and molecular processes that occur during cardiac wound healing is an essential prerequisite to reducing health burden and improve cardiac function after myocardial tissue damage. By integrating single-cell RNA-sequencing with imaging-based spatial transcriptomics, we reconstructed the spatio-temporal dynamics of the fibrotic niche after ventricular injury … Show more

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