The worldwide spread of Covid-19 infections has had a pervasive influence on cities and the lives of their residents. The current crisis has highlighted many urban problems, including those related to the functionality of urban structures, which directly affect the quality of life. Concurrently, the notion of “smart cities” is becoming a dominant trend in the discourse on urban development. At the intersection of these two phenomena, questions about the effects of Covid-19 on the future of cities arise. These are concerned with the possible roles of the pandemic in the process of urban regeneration and the development of smart solutions. The article aims to create a conceptual framework that will allow researchers to assess the influence of Covid-19-related changes on urban structures and their functionality in the following areas: city structure, connectivity and mobility, public spaces, access to green areas, and digital transformation. In the empirical part of the article, the influence of pandemic-caused changes on the development of various aspects of smart cities is discussed. The article concludes with an analysis of the effects the pandemic might have on digital urban regeneration.