Spatio-temporal relative risks and priority areas for visceral leishmaniasis control in Brazil, between 2001 and 2020

Melo, Saulo Nascimento de; Barbosa, David Soeiro; Bruhn, Fábio Raphael Pascoti; Câmara, Daniel Cardoso Portela; Simões, Taynãna César; Buzanovsky, Lia Puppim; Duarte, Anna Gabryela Sousa; Maia-Elkhoury, Ana Nilce Silveira; Cardoso, Diogo Tavares; Donato, Lucas Edel; Werneck, Guilherme Loureiro; Belo, Viní­cius Silva

doi:10.1016/j.actatropica.2023.106912

Cited by 5 publications

(1 citation statement)

References 42 publications

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“…The clinical spectrum of the disease is varied and depends on the interaction of several factors related to the parasite, the vector and the host, however, the visceral form of the disease is the most serious and can lead to death in up to 90% of untreated cases ( OPAS, 2021 ). Given its incidence and high lethality, this zoonosis is a worrying public health problem that mainly affects populations in developing countries, such as Brazil ( Lopes et al, 2023 ), accounting for 93.5% of visceral leishmaniasis cases in the Americas ( Melo et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Absence of Leishmania spp. DNA in road-killed wild mammals in Southern Brazil

Lignon,

Pinto,

Teles

et al. 2024

Rev. Bras. Parasitol. Vet.

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Leishmaniasis are neglected diseases transmitted by vectors that affect domestic and wild animals, including humans. Due to its incidence and lethality, this zoonosis is a worrying public health problem, making it essential to identify all links in the transmission chain. Infection of wild mammals by Leishmania spp. remains poorly understood, especially in southern Brazil. Therefore, the objective was to research, using the PCR technique, the presence of Leishmania spp. DNA in road-killed wild mammals in Southern Brazil. Carcasses of 96 animals were collected from highways in the Pelotas microregion, Rio Grande do Sul, southern Brazil and subjected to necropsies. Tissue fragments (spleen, skin, liver, kidney, heart, lung, lymph nodes, bone marrow and blood) were collected and genomic DNA was extracted. PCR protocols targeting the ITS1, kDNA and 18S genes were tested. We found no evidence of Leishmania spp. circulation in the studied population. However, epidemiological studies like this one are of great relevance, as they allow monitoring of the occurrence of pathogens and help identify possible risk areas. As these animals act as epidemiological markers for the presence of the microorganism, studies must be carried out continuously to understand whether there are sources of infection in the region.

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Section: Introductionmentioning

confidence: 99%