Spatio-temporal specification of olfactory bulb interneurons

Bovetti, Serena; Peretto, Paolo; Fasolo, Aldo; Marchis, Silvia De

doi:10.1007/s10735-007-9111-8

Cited by 22 publications

(21 citation statements)

References 50 publications

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“…Indeed, in other telencephalic regions, somatostatin is usually coexpressed with NPY and calbindin, rarely with CR and PV, and never with VIP (for a review, see Viollet et al, 2008). Such a striking difference may be due to a different developmental origin: hippocampal and cortical SRIF interneurons both originate from the median ganglionic eminence (Danglot et al, 2006;Métin et al, 2006;Wonders and Anderson, 2006), whereas most bulbar interneurons originate from the lateral ganglionic eminence and the dorsal telencephalon (Bovetti et al, 2007;Kohwi et al, 2007;Ventura and Goldman, 2007;Young et al, 2007).…”

Section: Somatostatin-ir Van Gehuchten Interneurons: Comparative Analmentioning

confidence: 99%

Somatostatin interneurons delineate the inner part of the external plexiform layer in the mouse main olfactory bulb

Lepousez

Csaba

Bernard

et al. 2010

J of Comparative Neurology

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Neuropeptides play a major role in the modulation of information processing in neural networks. Somatostatin, one of the most concentrated neuropeptides in the brain, is found in many sensory systems including the olfactory pathway. However, its cellular distribution in the mouse main olfactory bulb (MOB) is yet to be characterized. Here we show that approximately 95% of mouse bulbar somatostatin-immunoreactive (SRIF-ir) cells describe a homogeneous population of interneurons. These are restricted to the inner lamina of the external plexiform layer (iEPL) with dendritic field strictly confined to the region. iEPL SRIF-ir neurons share some morphological features of Van Gehuchten short-axon cells, and always express glutamic acid decarboxylase, calretinin, and vasoactive intestinal peptide. One-half of SRIF-ir neurons are parvalbumin-ir, revealing an atypical neurochemical profile when compared to SRIF-ir interneurons of other forebrain regions such as cortex or hippocampus. Somatostatin is also present in fibers and in a few sparse presumptive deep short-axon cells in the granule cell layer (GCL), which were previously reported in other mammalian species. The spatial distribution of somatostatin interneurons in the MOB iEPL clearly outlines the region where lateral dendrites of mitral cells interact with GCL inhibitory interneurons through dendrodendritic reciprocal synapses. Symmetrical and asymmetrical synaptic contacts occur between SRIF-ir dendrites and mitral cell dendrites. Such restricted localization of somatostatin interneurons and connectivity in the bulbar synaptic network strongly suggest that the peptide plays a functional role in the modulation of olfactory processing.

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Section: Somatostatin-ir Van Gehuchten Interneurons: Comparative Analmentioning

confidence: 99%

Somatostatin interneurons delineate the inner part of the external plexiform layer in the mouse main olfactory bulb

Lepousez

Csaba

Bernard

et al. 2010

J of Comparative Neurology

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“…The processes regulating newborn OB interneuron cell-fate, death or survival and synaptic maturation are poorly understood. Cell-autonomous mechanisms likely govern specification of OB interneurons early in their differentiation pathway through the expression of a combinatorial code of transcription factors (Bovetti et al, 2007c;De Marchis et al, 2007;Kohwi et al, 2007). Conversely activity plays an important role in SVZ-derived cell selection and synaptic integration.…”

Section: Integrationmentioning

confidence: 99%

From progenitors to integrated neurons: Role of neurotransmitters in adult olfactory neurogenesis

Bovetti

Gribaudo

Puché

et al. 2011

Journal of Chemical Neuroanatomy

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Adult neurogenesis is due to the persistence of pools of constitutive stem cells able to give rise to a progeny of proliferating progenitors. In rodents, adult neurogenic niches have been found in the subventricular zone (SVZ) along the lateral ventricles and in the subgranular zone of the dentate gyrus in the hippocampus. SVZ progenitors undergo a unique process of tangential migration from the lateral ventricle to the olfactory bulb (OB) where they differentiate mainly into GABAergic interneurons in the granule and glomerular layers. SVZ progenitor proliferation, migration and differentiation into fully integrated neurons, are strictly related processes regulated by complex interactions between cell intrinsic and extrinsic influences. Numerous observations demonstrate that neurotrasmitters are involved in all steps of the adult neurogenic process, but the understanding of their role is hampered by their intricate mechanism of action and by the highly complex network in which neurotransmitters work. By considering the three main steps of olfactory adult neurogenesis (proliferation, migration and integration), this review will discuss recent advances in the study of neurotransmitters, highlighting the regulatory mechanisms upstream and downstream their action.

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“…In the cerebral cortex, different interneuron categories originate from defined subsets of subpallial progenitors, whose developmental potentialities depend on their location [62][63][64] and on the time of their generation [45, 65,66]. Finally, the production of olfactory bulb interneurons is sustained by separate progenitor pools, restricted in space [67][68][69][70] and time [71][72][73]. Thus, while the most common strategy to generate the variety of CNS interneurons relies on dedicated precursors that differentiate according to cell-intrinsic programs, those of the cerebellum are produced by naive progenitors under the influence of extrinsic instructive cues.…”

Section: Concluding Remarks: a Peculiar Neurogenic Strategymentioning

confidence: 99%

Development of Cerebellar GABAergic Interneurons: Origin and Shaping of the “Minibrain” Local Connections

2008

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The cerebellar circuits comprise a limited number of neuronal phenotypes embedded in a defined cytoarchitecture and generated according to specific spatio-temporal patterns. The local GABAergic network is composed of several interneuron phenotypes that play essential roles in information processing by modulating the activity of cerebellar cortical inputs and outputs. A major issue in the study of cerebellar development is to understand the mechanisms that underlie the generation of different interneuron classes and regulate their placement in the cerebellar architecture and integration in the cortico-nuclear network. Recent findings indicate that the variety of cerebellar interneurons derives from a single population of multipotent progenitors whose fate choices are determined by instructive environmental information. Such a strategy, which is unique for the cerebellum along the neuraxis, allows great flexibility in the control of the quality and quantity of GABAergic interneurons that are produced, thus facilitating the adaptive shaping of the cerebellar network to specific functional demands.

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Spatio-temporal specification of olfactory bulb interneurons

Cited by 22 publications

References 50 publications

Somatostatin interneurons delineate the inner part of the external plexiform layer in the mouse main olfactory bulb

Somatostatin interneurons delineate the inner part of the external plexiform layer in the mouse main olfactory bulb

From progenitors to integrated neurons: Role of neurotransmitters in adult olfactory neurogenesis

Development of Cerebellar GABAergic Interneurons: Origin and Shaping of the “Minibrain” Local Connections

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