In the process of deep mining of coal resources, coal seams with better geological conditions are gradually mined preferentially, and the safe and efficient mining of working face in complex and heterogeneous spaces of residual coal seams is an urgent problem to be solved.. Based on the Kuangou Coal Mine as the background, using microseismic monitoring instruments and pressure sensor monitoring systems, the rock pressure appearance and microseismic energy characteristics accompanying the evolution of the overburden strata structure in the mining of solid coal and the lower working face of the gob are analyzed. Research on the precursory characteristics and early warning of micro-earthquakes. The research results show that: (1) The period of the W1123 working face mining under solid coal is relatively frequent, and the energy of microseismic events is higher than that under the mined-out area. However, the overlying rock structure under the gob is loose, broken and easy to move, showing obvious "high frequency-low energy" characteristics. (2) Extremely low values of the number and energy of microseismic events occurrs in the first 3 to 5 days of the rockburst event in the working face, and the locations of the rockburst disaster in the mine were generally distributed at the edge of the low-density area of the microseismic event. The accuracy of rockburst prediction is effectively improved through multi-parameter comprehensive early warning. (3) Roof deep hole blasting and roof cutting pressure relief weaken the roof energy accumulation and the concentrated release of rock formation energy, reduce the roof activity intensity in the microseismic event gathering area, and reduce the occurrence of large-energy events, which will easily induce large shock hazards. The energy event weakens into a slow release of multiple small energy events. This research provides a reference for the safe and efficient mining of working faces in complex space environment.