The northeastern part of Ethiopia, particularly Raya area is a pilgrimage site famed for its antique civilization, archaeological sites, and rural landscapes. Despite existing ecotourism potentials, the area has not been utilized for tourism for millennia. While previous work looked at the availability of natural resources, it did not identify and prioritize the resources, so knowledge gaps continue to exist in prioritization of potential ecotourism sites. This study attempted to identify various ecotourism indicators, evaluate and produce maps of suitable ecotourism sites, and prioritize optimum protected areas that are best suited for sustainable ecotourism development of Raya areas. For this analysis, 13 spatial indicators from physical, environmental, archaeological, socio-cultural, and socioeconomic sectors were considered. Analytic Hierarchical Process (AHP) was used to calculate the details of the spatial indicators and class weights. The suitability maps were classified into four classes as Highly Suitable (S1), Moderately Suitable (S2), Marginally Suitable (N1), and Not Suitable (N2). The results revealed 114.37 Km
2
(10.33%), 13.36 Km
2
(1.91%), and 10.39 Km
2
(1.62%) fall under the highly suitable class in Blocks B, A and C, respectively. AHP weights with ultimate criterion and field observations also ranked lake Ashenge, Hugumburda, and Gratkhassu national forest priority areas as 1st, 2nd, and 3rd optimal zones, respectively. The outcomes of this study are crucial for conservation pioneer work in ecological development, and should be used as an ideal blueprint by ecotourism planners and decision-makers for sustainable ecotourism development strategies.