The microstructure, mechanical properties and Portevin-Le Chatelier (PLC) effect in Ti-xMo alloys (x=10, 12, 15 and 18 wt%), in the temperature range of 250-350 °C with strain rates from 10-3 s-1 to 10-4 s-1 , are systematically investigated in tension by using transmission electron microscopy and Gleeble 3500 testing machine combined with a digital image correlation technique. Results show that Young modulus decreases with increasing Mo contents, which is related to a more stable β phase matrix and a decrease of ω phase fraction. Moreover, the values of Young modulus and 0.2% offset yield strength at elevated temperature are higher than the ones at room temperature in all the Ti-xMo alloys, except the Ti-18Mo alloy which shows an opposite result. These macroscopic features are consistent with the ω phase precipitation in deformed Ti-xMo alloys, due to the combined effects of ω phase strengthening and temperature softening. Furthermore, the serration type transforms from A to A+B, then to B and eventually to C as increasing temperature and decreasing strain rate as well as Mo contents, which mainly depends on the spatial cohesion of PLC bands influenced by the intensity of ω precipitate-dislocation interactions. Finally, the peak value of maximum stress drop magnitude appears in Ti-12Mo alloy and increases with decreasing the strain rate, which is attributed to a stronger intensity of ω precipitate-dislocation interactions caused by reducing dislocations movement and