Spatiotemporal Control of Immune Responses with Nucleic Acid Cocktail Vaccine
Chunxi Wang,
Andrew N. Macintyre,
Thomas H. Oguin
et al.
Abstract:Nucleic acid vaccines play important roles in the prevention and treatment of diseases. However, limited immunogenicity remains a major obstacle for DNA vaccine applications in the clinic. To address the issue, the present study investigates a cocktail approach to DNA vaccination. In this proof‐of‐the‐concept study, the cocktail consists of two DNAs encoding viral hemagglutinin (HA) and granulocyte‐macrophage colony stimulatory factor (GM‐CSF), respectively. Data from the study demonstrate that recruitment and… Show more
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