Amidst the pursuit of sustainable urban development, bolstering the spatial vitality of historic neighborhoods emerges as a pivotal endeavor. This study, centering on the Xicheng neighborhood in Ya’an City, employs a multifaceted data analysis approach to unravel the intricate spatial vitality patterns. By adopting a dual lens focusing on both “people” and “space”, we delve into the intricate interplay between spatial vitality, spatial perception, and various influencing factors, such as the spatial environment, business format layout, and place atmosphere. Leveraging spatial correlation analysis, we meticulously examine the extent to which these multifarious factors shape spatial vitality and perception. Our findings reveal a profound connection between the emotional dimension of perception and the distribution of spatial vitality. Notably, aspects of spatial character—green rating, accessibility, and interface richness—exert the most pronounced influence on vitality. Furthermore, the creation of a distinctive atmosphere in a place is more likely to resonate with a person’s spatial perception than the physical environment itself.