Spatiotemporal dynamics of influenza A(H1N1)pdm09 in Brazil during the pandemic and post-pandemic periods

Manito, Alessandra C.B.; Gräf, Tiago; Lunge, Vagner Ricardo; Ikuta, Nilo

doi:10.1016/j.virusres.2017.06.002

Cited by 3 publications

(3 citation statements)

References 36 publications

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“…Previous study has shown that after the emergence of A(H1N1)pdm09 virus in North America in 2009, the spatial transmission focus was heavily centered in Europe, Southeast Asia and South Asia during 2010–2014, which were similar to our findings [23]. Previous studies done in Brazil, 2009–2014 revealed that new influenza A(H1N1)pdm09 lineages are seeded in each year and the main sources of viral diversity are North America, Europe and East Asia [28]. Vietnam connected strongly with the United States but weakly with other Asian countries [29].…”

Section: Discussionsupporting

confidence: 89%

Phylogeographic analysis of human influenza A and B viruses in Myanmar, 2010–2015

et al. 2019

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We investigated the circulation patterns of human influenza A and B viruses in Myanmar between 2010 and 2015 by analyzing full HA genes. Upper respiratory tract specimens were collected from patients with symptoms of influenza-like illness. A total of 2,860 respiratory samples were screened by influenza rapid diagnostic test, of which 1,577 (55.1%) and 810 (28.3%) were positive for influenza A and B, respectively. Of the 1,010 specimens that were positive for virus isolation, 370 (36.6%) were A(H1N1)pdm09, 327 (32.4%) were A(H3N2), 130 (12.9%) B(Victoria), and 183 (18.1%) were B(Yamagata) viruses. Our data showed that influenza epidemics mainly occurred during the rainy season in Myanmar. Our three study sites, Yangon, Pyinmana, and Pyin Oo Lwin had similar seasonality and circulating type and subtype of influenza in a given year. Moreover, viruses circulating in Myanmar during the study period were closely related genetically to those detected in Thailand, India, and China. Phylogeographic analysis showed that A(H1N1)pdm09 viruses in Myanmar originated from Europe and migrated to other countries via Japan. Similarly, A(H3N2) viruses in Myanmar originated from Europe, and disseminated to the various countries via Australia. In addition, Myanmar plays a key role in reseeding of influenza B viruses to Southeast Asia and East Asia as well as Europe and Africa. Thus, we concluded that influenza virus in Myanmar has a strong link to neighboring Asian countries, Europe and Oceania.

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Section: Discussionsupporting

confidence: 89%

Phylogeographic analysis of human influenza A and B viruses in Myanmar, 2010–2015

et al. 2019

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“…We observed that most of the swine H1N1pdm09 sequences isolated in Brazil during this period resulted from single introductions ( p < 0.001), indicating a high proportion of self-limited infections with apparent extinction in swine. This finding is likely associated with the increased incidence of H1N1pdm09 among humans, where a higher IAV burden in the human population may lead to more interspecies spillover events ( Manito et al, 2017 ). Furthermore, viruses isolated during this phase exhibited higher global dN/dS rate ratios but did not show any positively selected sites.…”

Section: Discussionmentioning

confidence: 99%

Human-to-swine introductions and onward transmission of 2009 H1N1 pandemic influenza viruses in Brazil

et al. 2023

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IntroductionOnce established in the human population, the 2009 H1N1 pandemic virus (H1N1pdm09) was repeatedly introduced into swine populations globally with subsequent onward transmission among pigs.MethodsTo identify and characterize human-to-swine H1N1pdm09 introductions in Brazil, we conducted a large-scale phylogenetic analysis of 4,141 H1pdm09 hemagglutinin (HA) and 3,227 N1pdm09 neuraminidase (NA) gene sequences isolated globally from humans and swine between 2009 and 2022.ResultsPhylodynamic analysis revealed that during the period between 2009 and 2011, there was a rapid transmission of the H1N1pdm09 virus from humans to swine in Brazil. Multiple introductions of the virus were observed, but most of them resulted in self-limited infections in swine, with limited onward transmission. Only a few sustained transmission clusters were identified during this period. After 2012, there was a reduction in the number of human-to-swine H1N1pdm09 transmissions in Brazil.DiscussionThe virus underwent continuous antigenic drift, and a balance was established between swine-to-swine transmission and extinction, with minimal sustained onward transmission from humans to swine. These results emphasize the dynamic interplay between human-to-swine transmission, antigenic drift, and the establishment of swine-to-swine transmission in shaping the evolution and persistence of H1N1pdm09 in swine populations.

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“…Un estudio en Brasil (19 encontró que la diversidad viral de los nuevos linajes de la gripe A (H1N1) pdm09 provienen principalmente de América del Norte, Europa y Asia Oriental. Así mismo, la gravedad de la infección está asociada con el genoma del patógeno y del huésped, debido a la diversidad de resultados fatales y no fatales en persona de una misma región (20) .…”

Section: Discussionunclassified

Neumonía atípica por influenza A H1N1: reporte de casos en Lambayeque, Perú, 2018

Calderón-Flores

Yazawa-Ballena

2019

Rev Exp Med

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La influenza A H1N1 se diagnosticó por primera vez en México y Estados Unidos en abril del 2009. Esta pandemia es el resultado de una nueva cepa de virus de Influenza A que no se había identificado previamente en el humano. Los síntomas clínicos habituales de esta enfermedad pueden no distinguirse de la influenza estacional, e incluyen: tos, fiebre, mal estado general, odinofagia y dolores musculares. La complicación pulmonar de la influenza más frecuente es la neumonía. Se reportan dos casos de varones adultos provenientes de Bagua (ciudad de Perú con clima tropical); uno sin antecedentes patológicos, y el otro, inmunocomprometido. Ambos pacientes cursan con patrones clínico laboratoriales similares. La infección se confirmó mediante la prueba de reacción en cadena de la polimerasa con transcriptasa inversa (RT-PCR).

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Spatiotemporal dynamics of influenza A(H1N1)pdm09 in Brazil during the pandemic and post-pandemic periods

Cited by 3 publications

References 36 publications

Phylogeographic analysis of human influenza A and B viruses in Myanmar, 2010–2015

Phylogeographic analysis of human influenza A and B viruses in Myanmar, 2010–2015

Human-to-swine introductions and onward transmission of 2009 H1N1 pandemic influenza viruses in Brazil

Neumonía atípica por influenza A H1N1: reporte de casos en Lambayeque, Perú, 2018

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