2020
DOI: 10.21203/rs.3.rs-36174/v1
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Spatiotemporal expression of sonic hedgehog signaling molecules in the embryonic mesencephalic dopaminergic neurons

Abstract: Abstract Background Midbrain dopaminergic neurons (mDA) play an important role in controlling the voluntary motor movement, reward behavior and emotion-based behavior. Differentiation of mDA neurons from progenitors depends on a number of secreted proteins, such as sonic hedgehog (SHH), and transcription factors. Different groups from mDA neurons arise from the varied patterns of SHH expression during development. The present study attempted to elucidate 1) the possibl… Show more

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