Spatiotemporal Monitoring of High-Intensity Focused Ultrasound Therapy with Passive Acoustic Mapping

Jensen, Carl; Ritchie, Robert W.; Gyöngy, Miklós; Collin, James R. T.; Leslie, Tom; Coussios, Constantin C.

doi:10.1148/radiol.11110670

Cited by 134 publications

(110 citation statements)

References 27 publications

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“…However, the information obtained from a single-element PCD is fundamentally limited due to the inherent trade-off between the volume of sensitivity and spatial specificity of the device. The use of multielement arrays, combined with passive beamforming algorithms borrowed from other fields, [45][46][47][48] has been shown to overcome this limitation and enable spatial mapping of cavitation activity during the application of FUS in both in vitro [49][50][51][52][53][54][55][56][57][58][59][60][61][62] and in vivo [63][64][65][66][67] settings. The integration of passive imaging during mechanicalbased FUS brain therapies would make the procedures practical, by providing a method for real-time treatment monitoring and control.…”

Section: Introductionmentioning

confidence: 99%

Experimental demonstration of passive acoustic imaging in the human skull cavity using CT‐based aberration corrections

Jones

O’Reilly

Hynynen³

2015

Medical Physics

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Purpose: Experimentally verify a previously described technique for performing passive acoustic imaging through an intact human skull using noninvasive, computed tomography (CT)-based aberration corrections Jones et al. [Phys. Med. Biol. 58, 4981-5005 (2013)]. Methods: A sparse hemispherical receiver array (30 cm diameter) consisting of 128 piezoceramic discs (2.5 mm diameter, 612 kHz center frequency) was used to passively listen through ex vivo human skullcaps (n = 4) to acoustic emissions from a narrow-band fixed source (1 mm diameter, 516 kHz center frequency) and from ultrasound-stimulated (5 cycle bursts, 1 Hz pulse repetition frequency, estimated in situ peak negative pressure 0.11-0.33 MPa, 306 kHz driving frequency) Definity™ microbubbles flowing through a thin-walled tube phantom. Initial in vivo feasibility testing of the method was performed. The performance of the method was assessed through comparisons to images generated without skull corrections, with invasive source-based corrections, and with water-path control images. Results: For source locations at least 25 mm from the inner skull surface, the modified reconstruction algorithm successfully restored a single focus within the skull cavity at a location within 1.25 mm from the true position of the narrow-band source. The results obtained from imaging single bubbles are in good agreement with numerical simulations of point source emitters and the authors' previous experimental measurements using source-based skull corrections O'Reilly et al. [IEEE Trans. Biomed. Eng. 61, 1285-1294]. In a rat model, microbubble activity was mapped through an intact human skull at pressure levels below and above the threshold for focused ultrasound-induced blood-brain barrier opening. During bursts that led to coherent bubble activity, the location of maximum intensity in images generated with CT-based skull corrections was found to deviate by less than 1 mm, on average, from the position obtained using source-based corrections. Conclusions: Taken together, these results demonstrate the feasibility of using the method to guide bubble-mediated ultrasound therapies in the brain. The technique may also have application in ultrasound-based cerebral angiography. C 2015 American Association of Physicists in Medicine.

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Section: Introductionmentioning

confidence: 99%

Experimental demonstration of passive acoustic imaging in the human skull cavity using CT‐based aberration corrections

Jones

O’Reilly

Hynynen³

2015

Medical Physics

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“…The second important aspect for clinical translation is the presence of real-time treatment feedback to control for the desired physical effect on tissue; in the case of microbubbles, it is cavitation. Although simply imaging of the ultrasound contrast agent distribution has been utilized in diagnostic ultrasound for a long time, tools for mapping the degree of cavitation activity of the bubbles have only been reported recently [Jensen et al 2012;O'Reilly and Hynynen, 2013]. These tools are also ultrasound-based and rely on the emissions of harmonics and broadband ultrasound noise from the collapsing bubbles.…”

Section: Resultsmentioning

confidence: 99%

Therapeutic potential of ultrasound microbubbles in gastrointestinal oncology: recent advances and future prospects

Khokhlova

Haider

Hwang

2015

Therap Adv Gastroenterol

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Microbubbles were initially invented as contrast agents for ultrasound imaging. However, lately more and more therapeutic applications of microbubbles are emerging, mostly related to drug and gene delivery. Ultrasound is a safe and noninvasive therapeutic modality which has the unique ability to interact with microbubbles and release their payload in situ in addition to permeabilizing the target tissues. The combination of drug-loaded microbubbles and ultrasound has been used in preclinical studies on blood-brain barrier opening, drug and gene delivery to solid tumors, and ablation of blood vessels. This review covers the basic principles of ultrasound-microbubble interaction, the types of microbubbles and the effect they have on tissue, and the preclinical and clinical experience with this approach to date in the field of gastrointestinal oncology.

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“…10,11 Here, we use a passive technique similar to those previously used in acoustics 12 and seismic imaging, 13 modifications of which have more recently been investigated to map cavitation activity during ultrasound therapy. 14,15 With passive beamforming techniques both the phase and amplitude information of the received signals are considered and axial resolution primarily depends on frequency and array aperture, and not on pulse length. 16 Additionally, the intensity of the scatter response can be integrated over time to hugely improve the signal to noise ratio (SNR).…”

Section: Introductionmentioning

confidence: 99%

A super‐resolution ultrasound method for brain vascular mapping

2013

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Purpose: High-resolution vascular imaging has not been achieved in the brain due to limitations of current clinical imaging modalities. The authors present a method for transcranial ultrasound imaging of single micrometer-size bubbles within a tube phantom. Methods: Emissions from single bubbles within a tube phantom were mapped through an ex vivo human skull using a sparse hemispherical receiver array and a passive beamforming algorithm. Noninvasive phase and amplitude correction techniques were applied to compensate for the aberrating effects of the skull bone. The positions of the individual bubbles were estimated beyond the diffraction limit of ultrasound to produce a super-resolution image of the tube phantom, which was compared with microcomputed tomography (micro-CT). Results:The resulting super-resolution ultrasound image is comparable to results obtained via the micro-CT for small tissue specimen imaging. Conclusions: This method provides superior resolution to deep-tissue contrast ultrasound and has the potential to be extended to provide complete vascular network imaging in the brain.

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Spatiotemporal Monitoring of High-Intensity Focused Ultrasound Therapy with Passive Acoustic Mapping

Abstract: Passive acoustic mapping significantly outperformed the conventional hyperecho technique as an ultrasound-based HIFU monitoring method, as both a detector of lesion occurrence and a method of mapping the position of ablated tissue.

Cited by 134 publications

References 27 publications

Experimental demonstration of passive acoustic imaging in the human skull cavity using CT‐based aberration corrections

Experimental demonstration of passive acoustic imaging in the human skull cavity using CT‐based aberration corrections

Therapeutic potential of ultrasound microbubbles in gastrointestinal oncology: recent advances and future prospects

A super‐resolution ultrasound method for brain vascular mapping

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