2020
DOI: 10.1242/dev.180232
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Spatiotemporal regulation of GSK3β levels by miRNA-26a controls axon development in cortical neurons

Abstract: Both the establishment of neuronal polarity and axonal growth are crucial steps in the development of the nervous system. The local translation of mRNAs in the axon provides precise regulation of protein expression, and is now known to participate in axon development, pathfinding and synaptic formation and function. We have investigated the role of miR-26a in early stage mouse primary cortical neuron development. We show that micro-RNA-26a-5p (miR-26a) is highly expressed in neuronal cultures, and regulates bo… Show more

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Cited by 22 publications
(24 citation statements)
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“…MiR-26a, a brain-enriched microRNA mainly localized within axonal compartments of neurons, has been hypothesized to play a key role in axon development and regeneration (41,42), and also involved in the formation, maturation and/or plasticity of synapses via regulating distinct sets of target genes (43). For example, it has been suggested that miR-26a is involved in regulating excitatory neurotransmission under stress condition (44), and maintains stress resiliency and antidepressant efficacy by targeting the serotonergic autoreceptor (33).…”
Section: Discussionmentioning
confidence: 99%
“…MiR-26a, a brain-enriched microRNA mainly localized within axonal compartments of neurons, has been hypothesized to play a key role in axon development and regeneration (41,42), and also involved in the formation, maturation and/or plasticity of synapses via regulating distinct sets of target genes (43). For example, it has been suggested that miR-26a is involved in regulating excitatory neurotransmission under stress condition (44), and maintains stress resiliency and antidepressant efficacy by targeting the serotonergic autoreceptor (33).…”
Section: Discussionmentioning
confidence: 99%
“…Seminal studies have revealed that such a mechanism relies on the signal-induced retrograde transport of locally translated proteins to the nucleus to elicit transcription [ 8 , 79 , 80 , 81 ]. A recent study demonstrates that miRNAs play a crucial role in this process [ 76 ]. When miR-26a silencing of glycogen synthase kinase-3 beta ( Gsk3β ) transcripts is relieved in axons, newly synthesized GSK3β is transported to the soma, where it impacts axon polarization and outgrowth [ 76 ].…”
Section: At the Right Time: Axonal Mirna Regulate Mrna Translationmentioning
confidence: 99%
“…A recent study demonstrates that miRNAs play a crucial role in this process [ 76 ]. When miR-26a silencing of glycogen synthase kinase-3 beta ( Gsk3β ) transcripts is relieved in axons, newly synthesized GSK3β is transported to the soma, where it impacts axon polarization and outgrowth [ 76 ]. The localized role of miR-26a in axons was studied in mice primary cortical neurons using microfluidic devices.…”
Section: At the Right Time: Axonal Mirna Regulate Mrna Translationmentioning
confidence: 99%
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“…They were bred and sacrificed according to the UK Animal (Scientific Procedures) Act 1986. Primary cortical neuron cultures were obtained from C57/BL6 E16 mice brains as previously described (Lucci et al 2020…”
Section: Cell Culturesmentioning
confidence: 99%