Spatiotemporally controlled O<sub>2</sub> and singlet oxygen self-sufficient nanophotosensitizers enable the <i>in vivo</i> high-yield synthesis of drugs and efficient hypoxic tumor therapy

He, Suisui; Lu, Siyu; Li, Sha; Li, Tianrong; Li, Jieling; Sun, Shasha; Liu, Meilin; Liang, Kun; Fu, Xu; Chen, Fengjuan; Meng, Genping; Zhang, Lang; Hai, Jun; Wang, Baodui

doi:10.1039/d0sc02387f

Cited by 23 publications

(24 citation statements)

References 52 publications

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“…2.2 nm were homogeneously distributed on the PtMb nanoshuttle (Figure E). Moreover, it was also found that the high-resolution TEM (HRTEM) image of the PtMb nanoshuttle with a 0.22 nm of lattice spacing closely matched the spacing of the Pt(111) crystal plane …”

Section: Resultsmentioning

confidence: 78%

“…Recently, coordination polymer-based photosensitizers with specific structures have shown great potential for O 2 production because such structures can separate photosensitizers and well circumvent quenching induced by aggregation, thereby significantly improving 1 O 2 generation and the photothermal conversion efficiency. − Notably, the porous property of photosensitizer-based coordination polymers also increases the free diffusion of O 2 and 1 O 2 within and beyond frameworks, thereby remarkably strengthening the availability of various photosensitizers. However, the abovementioned porous coordination polymers are seldom exploited in imaging-guided multimodal synergistic treatment of hypoxic tumors.…”

Section: Introductionmentioning

confidence: 99%

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Shuttle-Shape Carrier-Free Platinum-Coordinated Nanoreactors with O₂ Self-Supply and ROS Augment for Enhanced Phototherapy of Hypoxic Tumor

Fu¹,

Yin²,

Shi

et al. 2021

ACS Appl. Mater. Interfaces

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The synergistic nanotheranostics of reactive oxygen species (ROS) augment or phototherapy has been a promising method within synergistic oncotherapy. However, it is still hindered by sophisticated design and fabrication, lack of a multimodal synergistic effect, and hypoxia-associated poor photodynamic therapy (PDT) efficacy. Herein, a kind of porous shuttle-shape platinum (IV) methylene blue (Mb) coordination polymer nanotheranostics-loaded 10-hydroxycamptothecin (CPT) is fabricated to address the abovementioned limitations. Our nanoreactors possess spatiotemporally controlled O2 self-supply, self-sufficient singlet oxygen (1O2), and outstanding photothermal effect. Once they are taken up by tumor cells, nanoreactors as a cascade catalyst can efficiently catalyze degradation of the endogenous hydrogen peroxide (H2O2) into O2 to alleviate tumor hypoxia. The production of O2 can ensure enhanced PDT. Subsequently, under both stimuli of external red light irradiation and internal lysosomal acidity, nanoreactors can achieve the on-demand release of CPT to augment in situ mitochondrial ROS and highly efficient tumor ablation via phototherapy. Moreover, under the guidance of near-infrared (NIR) fluorescent imaging, our nanoreactors exhibit strongly synergistic potency for treatment of hypoxic tumors while reducing damages against normal tissues and organs. Collectively, shuttle-shape platinum-coordinated nanoreactors with augmented ROS capacity and enhanced phototherapy efficiency can be regarded as a novel tumor theranostic agent and further promote the research of synergistic oncotherapy.

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Section: Resultsmentioning

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Shuttle-Shape Carrier-Free Platinum-Coordinated Nanoreactors with O₂ Self-Supply and ROS Augment for Enhanced Phototherapy of Hypoxic Tumor

Fu¹,

Yin²,

Shi

et al. 2021

ACS Appl. Mater. Interfaces

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“…In a recent work, He et al prepared a Pt(IV) methylene blue coordinated polymer (PtMBCP), and the size‐tunable and porous Pt NP/PtMBCP nanoshuttles (Pt/PtMBCPNSs) were fabricated via sequential topotactic conversions to achieve in vivo drug synthesis and cancer treatment ( Figure 23 a – c ). [ 105 ] As shown in Figure 23d , the TEM image of Pt/PtMBCPNSs indicated that the Pt NPs were uniformly distributed on the obtained nanoshuttles. The lattice spacing of the nanocrystal was determined to be 0.22 nm, which matched the spacing of the Pt (111) crystal lattice.…”

Section: Metal‐coordinated Supramolecular Self‐assemblies For Cancer Theranosticsmentioning

confidence: 97%

Metal‐Coordinated Supramolecular Self‐Assemblies for Cancer Theranostics

Wang

Jin

et al. 2021

Advanced Science

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Metal‐coordinated supramolecular nanoassemblies have recently attracted extensive attention as materials for cancer theranostics. Owing to their unique physicochemical properties, metal‐coordinated supramolecular self‐assemblies can bridge the boundary between traditional inorganic and organic materials. By tailoring the structural components of the metal ions and binding ligands, numerous multifunctional theranostic nanomedicines can be constructed. Metal‐coordinated supramolecular nanoassemblies can modulate the tumor microenvironment (TME), thus facilitating the development of TME‐responsive nanomedicines. More importantly, TME‐responsive organic–inorganic hybrid nanomaterials can be constructed in vivo by exploiting the metal‐coordinated self‐assembly of a variety of functional ligands, which is a promising strategy for enhancing the tumor accumulation of theranostic molecules. In this review, recent advancements in the design and fabrication of metal‐coordinated supramolecular nanomedicines for cancer theranostics are highlighted. These supramolecular compounds are classified according to the order in which the coordinated metal ions appear in the periodic table. Furthermore, the prospects and challenges of metal‐coordinated supramolecular self‐assemblies for both technical advances and clinical translation are discussed. In particular, the superiority of TME‐responsive nanomedicines for in vivo coordinated self‐assembly is elaborated, with an emphasis on strategies that enhance the accumulation of functional components in tumors for an ideal theranostic outcome.

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“…1,2 The therapeutic potential of chemotherapeutic drugs is limited by their low bioavailability and toxicity to normal cells. 3 To overcome the drawbacks of chemotherapy, nanocarriers have attracted extensive attention in anti-tumor research. 4,5 It is well known that the tumor microenvironment (TME) is different from normal tissue, with properties like higher acidicity and glutathione (GSH) concentration.…”

Section: Introductionmentioning

confidence: 99%

Targeted pH/redox dual-responsive nanoparticles for cancer chemotherapy combined with photodynamic/photothermal therapy

Chang

Wang

et al. 2022

New J. Chem.

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Spatiotemporally controlled O₂ and singlet oxygen self-sufficient nanophotosensitizers enable the in vivo high-yield synthesis of drugs and efficient hypoxic tumor therapy

Abstract: IIn vivo synthesis of toxic drugs against tumors based on the specific features of tumor microenvironment is critical to ensuring specific antitumor efficacy. However, how to achieve in situ high-yield...

Cited by 23 publications

References 52 publications

Shuttle-Shape Carrier-Free Platinum-Coordinated Nanoreactors with O₂ Self-Supply and ROS Augment for Enhanced Phototherapy of Hypoxic Tumor

Shuttle-Shape Carrier-Free Platinum-Coordinated Nanoreactors with O₂ Self-Supply and ROS Augment for Enhanced Phototherapy of Hypoxic Tumor

Metal‐Coordinated Supramolecular Self‐Assemblies for Cancer Theranostics

Targeted pH/redox dual-responsive nanoparticles for cancer chemotherapy combined with photodynamic/photothermal therapy

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Spatiotemporally controlled O2 and singlet oxygen self-sufficient nanophotosensitizers enable the in vivo high-yield synthesis of drugs and efficient hypoxic tumor therapy

Abstract: IIn vivo synthesis of toxic drugs against tumors based on the specific features of tumor microenvironment is critical to ensuring specific antitumor efficacy. However, how to achieve in situ high-yield...

Cited by 23 publications

References 52 publications

Shuttle-Shape Carrier-Free Platinum-Coordinated Nanoreactors with O2 Self-Supply and ROS Augment for Enhanced Phototherapy of Hypoxic Tumor

Shuttle-Shape Carrier-Free Platinum-Coordinated Nanoreactors with O2 Self-Supply and ROS Augment for Enhanced Phototherapy of Hypoxic Tumor

Metal‐Coordinated Supramolecular Self‐Assemblies for Cancer Theranostics

Targeted pH/redox dual-responsive nanoparticles for cancer chemotherapy combined with photodynamic/photothermal therapy

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Product

Resources

About

Spatiotemporally controlled O₂ and singlet oxygen self-sufficient nanophotosensitizers enable the in vivo high-yield synthesis of drugs and efficient hypoxic tumor therapy

Shuttle-Shape Carrier-Free Platinum-Coordinated Nanoreactors with O₂ Self-Supply and ROS Augment for Enhanced Phototherapy of Hypoxic Tumor

Shuttle-Shape Carrier-Free Platinum-Coordinated Nanoreactors with O₂ Self-Supply and ROS Augment for Enhanced Phototherapy of Hypoxic Tumor