sPD-L1 and sPD-L2 in plasma of patients with lung cancer and their clinical significance

Han, Shiyang; Zhang, Yan; Yuan, Jingzhi; Wu, Yi; Zhou, Yun; Zhou, Yan; Li, Xiaowei; Zhou, Shuru

doi:10.1016/j.cyto.2024.156532

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PD-L1 and PD-1 Are Associated with Clinical Outcomes and Alveolar Immune Cell Activation in Acute Respiratory Distress Syndrome

Morrell,

Holton,

Wiedeman

et al. 2024

Am J Respir Cell Mol Biol

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PD-L1 and PD-1 Are Associated with Clinical Outcomes and Alveolar Immune Cell Activation in Acute Respiratory Distress Syndrome

Morrell,

Holton,

Wiedeman

et al. 2024

Am J Respir Cell Mol Biol

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B7-H3 regulates HK2 expression and promotes the PI3K/AKT/mTOR pathway

Han,

Wu,

Zhang

et al. 2025

Preprint

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Background Lung cancer is the foremost cause of cancer-related mortality globally. B7-H3, an immune checkpoint, not only has immunomodulatory functions but also promotes tumor cell proliferation, drug resistance, metastasis, and aerobic glycolysis. The specific role of B7-H3 in aerobic glycolysis in lung cancer has not yet been elucidated. Methods B7-H3 expression was validated in lung cancer tissues and lung cancer cell lines. Overexpression and knockout experiments were conducted in lung cancer cell lines to assess cell proliferation, migration, lactate production, and glucose consumption. The expression of hexokinase 2 (HK2) and the PI3K/Akt/mTOR signaling pathway were analyzed. Additionally, soluble B7-H3 (sB7-H3) along with lactate levels in the plasma of lung cancer patients were measured, and the clinical characteristics were analysed. Results B7-H3 was highly expressed in lung cance tissue and lung cancer cell lines, and enhanced the proliferation and migration, along with increased lactate production and glucose consumption rates. Our study also demonstrated that B7-H3 regulates the expression of HK2, thereby promoting the proliferation and migration of lung cancer cells through the PI3K/Akt/mTOR signaling pathway. Furthermore, sB7-H3 levels was postively correlated with the lacte levels in the plasma of lung cancer patients, and high sB7-H3 levels were associated with a poorer prognosis. Conclusion The research suggests that B7-H3 affects lung cancer cell proliferation and migration by enhancing aerobic glycolysis via HK2, providing a new perspective for the application of B7-H3 in clinical prognosis and treatment.

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sPD-L1 and sPD-L2 in plasma of patients with lung cancer and their clinical significance

Cited by 2 publications

References 35 publications

PD-L1 and PD-1 Are Associated with Clinical Outcomes and Alveolar Immune Cell Activation in Acute Respiratory Distress Syndrome

PD-L1 and PD-1 Are Associated with Clinical Outcomes and Alveolar Immune Cell Activation in Acute Respiratory Distress Syndrome

B7-H3 regulates HK2 expression and promotes the PI3K/AKT/mTOR pathway

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