Speaker Abstracts

Cisplatin Nanoliposomes for Cancer Therapy: AFM and Fluorescence Imaging of Cisplatin Encapsulation, Stability, Cellular Uptake, and Toxicity

“…Considerable effort is being put into engineering means to maintain sustained effective intracellular concentration at low systemic doses. , Liposome-based drug formulations have resulted in better drug delivery to the target tissues in a selective manner with drastic reduction in systemic dose and concomitant systemic toxicity, which improves the patient compliance and effectiveness of the treatment more than do free drug preparations . A liposome-based delivery of cisplatin would be beneficial for several reasons: (a) high cisplatin encapsulation in small nanometric liposomes would increase the efficiency of cellular uptake significantly, which would increase the therapeutic index of cisplatin and thereby overcome the concentration-associated drug resistance effects; − (b) selective targeting could be achieved by engineering the lipids with cell specific markers, which in turn would result in effective containment of the disease without indiscriminate killing of normal healthy tissues. − …”