Speaking rate effects on articulatory pattern consistency in talkers with mild ALS

Mefferd, Antje S.; Pattee, Gary L.; Green, Jordan R.

doi:10.3109/02699206.2014.908239

Cited by 53 publications

(55 citation statements)

References 34 publications

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“…Early in the disease speech patterns are consistent during typical speech, indicating successful adaption to disease-related articulatory deficits. However, during fast speech, patterns become inconsistent indicating impaired articulatory control when the speech motor system operates near its performance limit (Mefferd et al , 2014). In some patients with isolated speech deficits, FDG-PET studies, have shown subtle hypometabolism affecting the premotor and motor cortices (Clark et al , 2014).…”

Section: Mirror Neurons In Language and Gesturementioning

confidence: 99%

Does dysfunction of the mirror neuron system contribute to symptoms in amyotrophic lateral sclerosis?

Eisen

Lemon

Kiernan

et al. 2015

Clinical Neurophysiology

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Eisen et al, Mirror Neurons in ALS 2 Declaration of interest:The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper. Eisen et al, Mirror Neurons in ALS 3 Abbreviations:ALS: Amyotrophic lateral sclerosis; ADM: adductor digiti minimi; APB: abductor pollicic brevis; bvFTD: Behavioral variant of frontotemporal dementia; FTD: Frontotemporal dementia; fMRI: functional MRI; MNS: Mirror neuron system; M1: Primary motor cortex; PTNs: Pyramidal tract neurons; vMPFC: Ventral medial prefrontal cortex. Eisen et al, Mirror Neurons in ALS 4 AbstractThere is growing evidence that mirror neurons, initially discovered over two decades ago in the monkey, are present in the human brain. In the monkey, mirror neurons characteristically fire not only when it is performing an action, such as grasping an object, but also when observing a similar action performed by another agent (human or monkey). In this review we discuss the origin, cortical distribution and possible functions of mirror neurons as a background to exploring their potential relevance in amyotrophic lateral sclerosis (ALS). We have recently proposed that ALS (and the related condition of frontotemporal dementia) may be viewed as a failure of interlinked functional complexes having their origins in key evolutionary adaptations. The mirror neuron system is considered by many to be the basis of primates' social cognition, with a clear evolutionary advantage. Impaired empathy and motor control has been related to a defective mirror neuron system. In ALS, the mirror neuron system might be implicated in empathy, the split-hand syndrome, gait, speech, and related languagegesture impairments.Eisen et al, Mirror Neurons in ALS 5

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Section: Mirror Neurons In Language and Gesturementioning

confidence: 99%

Does dysfunction of the mirror neuron system contribute to symptoms in amyotrophic lateral sclerosis?

Eisen

Lemon

Kiernan

et al. 2015

Clinical Neurophysiology

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“…In addition, speaking rate may be significantly impacted by losses in articulatory function while only minimally affected by losses in the resonatory and phonatory functions [14, 15]. Therefore, measures of bulbar impairment that rely on speaking rate may be insensitive to cases of ALS that are characterized by resonatory or phonatory impairment onset.…”

Section: Introductionmentioning

confidence: 99%

Predicting Early Bulbar Decline in Amyotrophic Lateral Sclerosis: A Speech Subsystem Approach

Rong

Yunusova

Wang

et al. 2015

Behavioural Neurology

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Purpose. To develop a predictive model of speech loss in persons with amyotrophic lateral sclerosis (ALS) based on measures of respiratory, phonatory, articulatory, and resonatory functions that were selected using a data-mining approach. Method. Physiologic speech subsystem (respiratory, phonatory, articulatory, and resonatory) functions were evaluated longitudinally in 66 individuals with ALS using multiple instrumentation approaches including acoustic, aerodynamic, nasometeric, and kinematic. The instrumental measures of the subsystem functions were subjected to a principal component analysis and linear mixed effects models to derive a set of comprehensive predictors of bulbar dysfunction. These subsystem predictors were subjected to a Kaplan-Meier analysis to estimate the time until speech loss. Results. For a majority of participants, speech subsystem decline was detectible prior to declines in speech intelligibility and speaking rate. Among all subsystems, the articulatory and phonatory predictors were most responsive to early bulbar deterioration; and the resonatory and respiratory predictors were as responsive to bulbar decline as was speaking rate. Conclusions. The articulatory and phonatory predictors are sensitive indicators of early bulbar decline due to ALS, which has implications for predicting disease onset and progression and clinical management of ALS.

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“…However, there is an alternative explanation. Mefferd et al (2014) reported highly variable patterns of jaw movements during sentence productions at a mild stage of ALS and suggested that an increase in jaw speed may simply reflect an initial loss of articulatory control. As hypothesized, however, our data showed that, when speaking rate declined, the tongue and jaw showed an opposing pattern of movements-the tongue decreased in speed, whereas the jaw increased in speed.…”

Section: Longitudinal Changes At An Early Stage Of Bulbar Diseasementioning

confidence: 99%

“…System-level measures are influenced by all physiological subsystems of speech-respiratory, resonatory, phonatory, and articulatory-at the same time, and numerous compensatory strategies across subsystems can be used to maintain intelligibility and speaking rate (Mefferd et al, 2014). Hence, there is a need to evaluate individual subsystems to identify measures that may be indicative of early changes in the bulbar mechanism.…”

mentioning

confidence: 99%

“…Because speaking rate declines earlier and in a linear manner as compared with speech intelligibility, it is currently considered the clinical gold standard for monitoring the progression of bulbar disease (Ball et al, 2001;Green, Yunusova, et al, 2013;Yorkston, 1993;Yorkston & Beukelman, 1981). For this reason, speaking rate has often been used for the clinical subgrouping of patients on the basis of their severities of bulbar impairment (Mefferd, Pattee, & Green, 2014;Yorkston & Beukelman, 1981;Yunusova et al, 2010).…”

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confidence: 99%

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Speech Movement Measures as Markers of Bulbar Disease in Amyotrophic Lateral Sclerosis

Shellikeri

Green

Kulkarni

et al. 2016

J Speech Lang Hear Res

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Purpose: The goal of this study was to identify the effects of amyotrophic lateral sclerosis (ALS) on tongue and jaw control, both cross-sectionally and longitudinally. The data were examined in the context of their utility as a diagnostic marker of bulbar disease. Method: Tongue and jaw movements were recorded crosssectionally (n = 33 individuals with ALS, 13 controls) and longitudinally (n = 10 individuals with ALS) using a threedimensional electromagnetic articulography system during the production of the sentence Buy Bobby a puppy. The movements were examined for evidence of changes in size, speed, and duration and with respect to disease severity and time in the study.Results: Maximum speed of tongue movements and movement durations were significantly different only at an advanced stage of bulbar ALS compared with the healthy control group. The longitudinal analysis revealed a reduction in tongue movement size and speed with time at early stages of disease, which was not seen cross-sectionally. As speaking rate declined, tongue movements decreased in maximum speed, whereas jaw movements increased in maximum speed. Conclusions: Longitudinal analyses of sentence-level kinematic data show their sensitivity to early bulbar impairment. A change in articulatory kinematics can serve as a useful diagnostic marker for bulbar ALS and to track bulbar disease progression in a clinical setting.

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Speaking rate effects on articulatory pattern consistency in talkers with mild ALS

Cited by 53 publications

References 34 publications

Does dysfunction of the mirror neuron system contribute to symptoms in amyotrophic lateral sclerosis?

Does dysfunction of the mirror neuron system contribute to symptoms in amyotrophic lateral sclerosis?

Predicting Early Bulbar Decline in Amyotrophic Lateral Sclerosis: A Speech Subsystem Approach

Speech Movement Measures as Markers of Bulbar Disease in Amyotrophic Lateral Sclerosis

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