This open-access article is distributed under Creative Commons licence CC-BY-NC 4.0. Over the past decade, adolescent interest in recreational substances has expanded beyond the use of alcohol and/or cannabis. Rather, adolescents are increasingly using substances that offer alternative modes of usage, such as whoonga (a low-grade form of heroin that is smoked in conjunction with cannabis) [1] and, more recently, over-thecounter cough medicine (OTCCM) that contains codeine [2] or high levels of alcohol (hereafter referred to as 'cough syrup'). In South Africa (SA), the use of cough syrup as a recreational drug is a relatively new but rapidly growing phenomenon. Through the broader research study on which the current paper is based, we found that one-quarter (n=52) of our sample (N=205) reported having used cough syrup recreationally. Among this subgroup of recreational users, most (n=31) indicated that they first used this substance at 15-17 years of age. Cough syrups are generally consumed as a cocktail mixed with fizzy sodas or fruit juices, and this concoction is globally referred to as 'lean' , 'sizzurp' , 'purple drank' , 'dirty sprite' [3] or 'double cupping, ' [4] among others. 'Lean' has been popularised in rap and hip-hop music since the 1990s, [3] and is increasingly referenced in SA hip-hop. Anecdotal evidence, presented in print, television and social media, suggests that young people prefer cough syrups that contain alcohol or codeine, given the euphoric effects associated with their usage. [4,5] Excessive use of products containing codeine may lead to withdrawal symptoms, including cravings and a preoccupation with using codeine products, [6] and 'lean' use has also been associated with serious brain damage, [7] illicit drug abuse, and heightened risk of polydrug addiction. [8] Similarly, the abuse of alcohol is associated with adverse health and behavioural consequences, and may lead to adulthood dependence. [9,10] Research has documented cough syrup abuse in China and Hong Kong, [11-13] India [14,15] and the USA. [3,16-18] However, research on cough syrup misuse in SA is limited, although some research has explored adult use of codeine-based OTC tablets. [6] There is therefore a paucity of SA research pertaining to adolescents' misuse of cough syrups. The current paper addresses this gap by describing SA adolescents' views of cough syrup misuse, and the factors that may promote misuse. Methods The present paper is based on results from a larger mixed-methods study that explored underage drinking in two low-resourced townships in Mpumalanga and Free State provinces, SA. The paper presents qualitative findings on adolescents' knowledge and perceptions of recreational cough syrup use. Participants in Grades 10-12 were recruited at four schools in two townships. Participants were eligible if they were <18 years old, volunteered to participate and provided consent (parental consent and adolescent assent). All eligible participants' names were compiled and 72 learners per township were randomly selected ...