Special axo‐dendritic synapses in the hippocampal cortex: Electron and light microscopic studies on the layer of mossy fibers

Blackstad, Theodor W.; Kjærheim, Å

doi:10.1002/cne.901170202

Cited by 358 publications

(144 citation statements)

References 13 publications

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“…The mossy fibers are projection axons of the hippocampal granule cells in the dentate gyrus, sending signals to the CA3 region. The MFB is an enlarged axon terminal (3)(4)(5) μm in diameter) forming synaptic contacts onto CA3 neurons [23][24][25] . In hippocampal slices maintained in vitro, it is possible to make simultaneous paired recording from the soma and the MFB of a given granule cell, or a presynaptic MFB and a postsynaptic CA3 pyramidal neuron.…”

Section: Establishment Of the Tight-seal Patch-clamp Techniquementioning

confidence: 99%

Axonal bleb recording

Shu

2012

Neurosci. Bull.

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Patch-clamp recording requires direct accessibility of the cell membrane to patch pipettes and allows the investigation of ion channel properties and functions in specific cellular compartments. The cell body and relatively thick dendrites are the most accessible compartments of a neuron, due to their large diameters and therefore great membrane surface areas. However, axons are normally inaccessible to patch pipettes because of their thin structure; thus studies of axon physiology have long been hampered by the lack of axon recording methods. Recently, a new method of patchclamp recording has been developed, enabling direct and tight-seal recording from cortical axons. These recordings are performed at the enlarged structure (axonal bleb) formed at the cut end of an axon after slicing procedures. This method has facilitated studies of the mechanisms underlying the generation and propagation of the main output signal, the action potential, and led to the finding that cortical neurons communicate not only in action potential-mediated digital mode but also in membrane potential-dependent analog mode.

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Section: Establishment Of the Tight-seal Patch-clamp Techniquementioning

confidence: 99%

Axonal bleb recording

Shu

2012

Neurosci. Bull.

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“…A single axon can contain several thousands of boutons 48,49,51 . Bouton size varies between ~1 µm for thin unmyelinated axons 52,53 , to between 3 and 5 µm for large mossy fibre terminals of the hippocampus 53,54 . Their density varies among axons and the spacing between varicosities ranges from ~4 µm to ~6 µm in unmyelinated axons 53,55 .…”

Section: Axonal Propagation and Spike Timingmentioning

confidence: 99%

Information processing in the axon

2004

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“…The proximal segments of the apical dendrites of CA3 pyramidal cell neurons are associated with complex spines, or excrescences, which receive mossyfiber input from granule cell neurons of the DG (58). Neural activity from the entorhinal cortex activates mossy-fiber projections from the DG to the CA3 pyramidal region and is proposed to mediate dendritic remodeling in that region (7).…”

Section: The Effect Of Chronic Stress and Lithium Treatment On Behaviormentioning

confidence: 99%

Stress-induced structural remodeling in hippocampus: Prevention by lithium treatment

Wood

Young²,

Reagan³

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

183

121

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Chronic restraint stress, psychosocial stress, as well as systemic or oral administration of the stress-hormone corticosterone induces a morphological reorganization in the rat hippocampus, in which adrenal steroids and excitatory amino acids mediate a reversible remodeling of apical dendrites on CA3 pyramidal cell neurons of the hippocampus. This stress-induced neuronal remodeling is accompanied also by behavioral changes, some of which can be prevented with selective antidepressant and anticonvulsive drug treatments. Lithium is an effective treatment for mood disorders and has neuroprotective effects, which may contribute to its therapeutic properties. Thus, we wanted to determine whether lithium treatment could prevent the effects of chronic stress on CA3 pyramidal cell neuroarchitecture and the associated molecular and behavioral measures. Chronic lithium treatment prevented the stress-induced decrease in dendritic length, as well as the stressinduced increase in glial glutamate transporter 1 (GLT-1) mRNA expression and the phosphorylation of cAMP-response element binding in the hippocampus. Lithium treatment, however, did not prevent stress effects on behavior in the open field or the plusmaze. These data demonstrate that chronic treatment with lithium can protect the hippocampus from potentially deleterious effects of chronic stress on glutamatergic activation, which may be relevant to its therapeutic efficacy in the treatment of major depressive disorder and bipolar disorder.

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Special axo‐dendritic synapses in the hippocampal cortex: Electron and light microscopic studies on the layer of mossy fibers

Cited by 358 publications

References 13 publications

Axonal bleb recording

Axonal bleb recording

Information processing in the axon

Stress-induced structural remodeling in hippocampus: Prevention by lithium treatment

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