Special clinicopathological features of anaplastic diffuse large B-cell lymphoma: a case report and literature review

Abstract

Anaplastic diffuse large B-cell lymphoma (A- DLBCL) is a mysterious and rare disease, its histopathological features have not been fully clarified toaday. This paper provides a case in the left axillary lymph node, there are a large number of pleomorphic centroblast-like cells with anaplastic characteristics and HRS-like cells in a nodular or follicular germinating center-like growth, which is consistent with diffuse large B-cell lymphoma, non-special type, anaplastic subtype. The results of immunohistochemistry showed that these tumor cells were positive for CD20, CD79ɑ, Pax5, LMO2, BCL6, IgD. Besides, CD21 showed FDC network and p53 was diffusely and strongly positive. Ki67 proliferation index was 80 ~ 90%. Tumor cells were no association with EB virus (EBV). Our case presents different morphological diversity from previously reported cases of A-DLBCL, which shows different clinicopathological features with common diffuse large B-cell lymphoma (DLBCL) and anaplastic large cell lymphoma (ALCL). Furthermore, we also review the most of article about ALCL and summarize the progress of its pathogenesis, treatment and prognosis in recent years.