Special Collection: Closing the Gaps in Skin Wound Healing

Kearney, Cathal J.; Pandit, Abhay

doi:10.1089/ten.tea.2015.0549

Cited by 2 publications

(2 citation statements)

References 11 publications

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“…Chronic wounds affect approximately 2.4 to 4.5 million people in the United States, and over half of the nontraumatic lower extremity amputations are due to diabetic foot ulcers 1,2 . The World Health Organization estimates that over 350 million people globally are affected by Type I and II diabetes with 15% of those patients suffering from diabetic foot ulcers 3,4 . Diabetic foot ulcerations are highly prevalent due to underlying health complications and delayed healing times.…”

Section: Introductionmentioning

confidence: 99%

Bactericidal activity of 3D-printed hydrogel dressing loaded with gallium maltolate

et al. 2019

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Chronic wounds are projected to reach epidemic proportions worldwide because of the aging population and the increasing incidence of diabetes. Despite extensive research, infection remains one of the leading sources of complications in chronic wounds, resulting in improper healing, biofilm formation, and lower extremity amputation. To address the limitations of standard treatments, we have developed a hydrogel wound dressing with self-tuning moisture control that incorporates a novel antimicrobial agent to eliminate and prevent infection. 3D-printing of a hydrogel dressing with dual porosity resulted in a new dressing with greater flexibility, increased water uptake, and more rapid swelling than bulk hydrogel dressings. Additionally, gallium maltolate (GaM) was incorporated into the dressing to investigate the efficacy of this antimicrobial agent. Loading profiles, release kinetics, and the bactericidal activity against Staphylococcus aureus (including methicillin-resistant Staphylococcus aureus ) of GaM were investigated in vitro to identify target profiles that supported infection control. Finally, GaM-loaded hydrogel dressings were evaluated in vivo , utilizing a murine splinted-wound model that was inoculated with S. aureus . In comparison to an untreated control, GaM dressings markedly reduced the wound bacterial load without compromising wound closure rates. Overall, this work demonstrates the utility of a 3D-printed hydrogel dressing as an antimicrobial dressing to control infection in chronic wounds.

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Section: Introductionmentioning

confidence: 99%

Bactericidal activity of 3D-printed hydrogel dressing loaded with gallium maltolate

et al. 2019

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“…No basis for a statistically consolidated statement existed, so that the decision was taken to repeat the tests with a higher number of measurements (n = 100). The basic properties of the porcine skin used in the pilot test (collagen content) meant it could only at best be considered as a temporary skin substitute [3]. The new measurements were conducted using tempered human cadaver skin so that results could be obtained that were much more clinically relevant.…”

Section: Introductionmentioning

confidence: 99%