Special features of neuroendocrine interactions between stress and reproduction in teleosts

Rousseau, Karine; Prunet, Patrick; Dufour, Sylvie

doi:10.1016/j.ygcen.2020.113634

Cited by 25 publications

(9 citation statements)

References 416 publications

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“…Plasma cortisol is an established indicator of stress in fishes (Mommsen et al, 1999;Sadoul and Geffroy, 2019), produced by the Hypothalamus-Pituitary-Interrenal (HPI) axis, it plays a key role in energy mobilization to cope with stressful events (Sadoul and Vijayan, 2016) but it may also have multiple other impacts, notably on reproduction (Rousseau et al, 2021) or sex determination (Geffroy and Douhard, 2019). Basal circulating cortisol titer can vary in response to life-history (Ricklefs and Wikelski, 2002), body condition (Breuner and Hahn, 2003) and season (Landys et al, 2006;Love et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Group size, temperature and body size modulate the effects of social hierarchy on basal cortisol levels in fishes

Bessa

Sadoul

McKenzie

et al. 2021

Hormones and Behavior

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Section: Introductionmentioning

confidence: 99%

Group size, temperature and body size modulate the effects of social hierarchy on basal cortisol levels in fishes

Bessa

Sadoul

McKenzie

et al. 2021

Hormones and Behavior

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“…Similarly, in the ovary, CRH1 inhibits steroid biosynthesis as shown in vitro [rat and human granulosa cells: (124); human granulosa-lutein cells: (125); human thecal cells: (126); mouse preantral follicles: (127)]. Altogether these data suggest a conserved direct inhibitory role of CRH1 on gonadal steroidogenesis in vertebrates, which may participate, together with interactions between neuroendocrine axes, in the wellknown stress-related impairment of reproduction, as observed in many species [for review (128)]. In teleosts, this role of CRH1 on the gonads may likely be fulfilled by either one or the other crh1 paralog according to species.…”

Section: Potential Autocrine/paracrine Roles Of Crh1 Paralogs In Vari...mentioning

confidence: 82%

New Insights Into the Evolution of Corticotropin-Releasing Hormone Family With a Special Focus on Teleosts

Maugars

Mauvois

Martin³

et al. 2022

Front. Endocrinol.

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Corticotropin-releasing hormone (CRH) was discovered for its role as a brain neurohormone controlling the corticotropic axis in vertebrates. An additional crh gene, crh2, paralog of crh (crh1), and likely resulting from the second round (2R) of vertebrate whole genome duplication (WGD), was identified in a holocephalan chondrichthyan, in basal mammals, various sauropsids and a non-teleost actinopterygian holostean. It was suggested that crh2 has been recurrently lost in some vertebrate groups including teleosts. We further investigated the fate of crh1 and crh2 in vertebrates with a special focus on teleosts. Phylogenetic and synteny analyses showed the presence of duplicated crh1 paralogs, crh1a and crh1b, in most teleosts, resulting from the teleost-specific WGD (3R). Crh1b is conserved in all teleosts studied, while crh1a has been lost independently in some species. Additional crh1 paralogs are present in carps and salmonids, resulting from specific WGD in these lineages. We identified crh2 gene in additional vertebrate groups such as chondrichthyan elasmobranchs, sarcopterygians including dipnoans and amphibians, and basal actinoperygians, Polypteridae and Chondrostei. We also revealed the presence of crh2 in teleosts, including elopomorphs, osteoglossomorphs, clupeiforms, and ostariophysians, while it would have been lost in Euteleostei along with some other groups. To get some insights on the functional evolution of the crh paralogs, we compared their primary and 3D structure, and by qPCR their tissue distribution, in two representative species, the European eel, which possesses three crh paralogs (crh1a, crh1b, crh2), and the Atlantic salmon, which possesses four crh paralogs of the crh1-type. All peptides conserved the structural characteristics of human CRH. Eel crh1b and both salmon crh1b genes were mainly expressed in the brain, supporting the major role of crh1b paralogs in controlling the corticotropic axis in teleosts. In contrast, crh1a paralogs were mainly expressed in peripheral tissues such as muscle and heart, in eel and salmon, reflecting a striking subfunctionalization between crh1a and b paralogs. Eel crh2 was weakly expressed in the brain and peripheral tissues. These results revisit the repertoire of crh in teleosts and highlight functional divergences that may have contributed to the differential conservation of various crh paralogs in teleosts.

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“…Although recent findings in zebrafish suggest that cortisol can also act as a promoter of spermatogenesis [ 219 ], elevated cortisol levels in fish are generally agreed to inhibit reproduction (for review see Rousseau et al . [ 220 ]). Considering the stable hierarchies in which our experimental animals had been living, downregulation of genes from the stress axis in d-males thus reflects their well-established social rank and active reproduction.…”

Section: Discussionmentioning

confidence: 99%

Transcriptomes of testis and pituitary from male Nile tilapia (O. niloticus L.) in the context of social status

et al. 2022

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African cichlids are well established models for studying social hierarchies in teleosts and elucidating the effects social dominance has on gene expression. Ascension in the social hierarchy has been found to increase plasma levels of steroid hormones, follicle stimulating hormone (Fsh) and luteinizing hormone (Lh) as well as gonadosomatic index (GSI). Furthermore, the expression of genes related to gonadotropins and steroidogenesis and signaling along the brain-pituitary-gonad axis (BPG-axis) is affected by changes of an animal’s social status. In this study, we use RNA-sequencing to obtain an in-depth look at the transcriptomes of testes and pituitaries from dominant and subordinate male Nile tilapia living in long-term stable social hierarchies. This allows us to draw conclusions about factors along the brain-pituitary-gonad axis that are involved in maintaining dominance over weeks or even months. We identify a number of genes that are differentially regulated between dominant and subordinate males and show that in high-ranking fish this subset of genes is generally upregulated. Genes differentially expressed between the two social groups comprise growth factors, related binding proteins and receptors, components of Wnt-, Tgfβ- and retinoic acid-signaling pathway, gonadotropin signaling and steroidogenesis pathways. The latter is backed up by elevated levels of 11-ketotestosterone, testosterone and estradiol in dominant males. Luteinizing hormone (Lh) is found in higher concentration in the plasma of long-term dominant males than in subordinate animals. Our results both strengthen the existing models and propose new candidates for functional studies to expand our understanding of social phenomena in teleost fish.

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Special features of neuroendocrine interactions between stress and reproduction in teleosts

Cited by 25 publications

References 416 publications

Group size, temperature and body size modulate the effects of social hierarchy on basal cortisol levels in fishes

Group size, temperature and body size modulate the effects of social hierarchy on basal cortisol levels in fishes

New Insights Into the Evolution of Corticotropin-Releasing Hormone Family With a Special Focus on Teleosts

Transcriptomes of testis and pituitary from male Nile tilapia (O. niloticus L.) in the context of social status

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