Special Housing Arrangements

Dennis, Mike

doi:10.1002/9781444318777.ch11

The UFAW Handbook on the Care and Management of Laboratory and Other Research Animals 2010

DOI: 10.1002/9781444318777.ch11

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Special Housing Arrangements

Mike Dennis¹

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Cited by 2 publications

References 27 publications

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Facility design and management. Strategies for high level biocontainment

Dennis,

Charlton,

Elam

et al. 2024

Lab Anim

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UK Health Security Agency is required to investigate the pathogenesis of emerging or re-emerging infections and to test novel interventions, such as vaccines and therapeutics against these and other diseases, such as tuberculosis and Ebola, that have a significant impact on human health world-wide. Research into the causative agents (mainly BSL 3 and 4) using a wide range of animal species as pre-clinical models brings a number of challenges in terms of effective biocontainment to address human safety whilst optimising delivery of scientific objectives and the welfare of the animals. Here we describe the strategies used for high containment of species that include mice, ferrets, hamsters, rabbits and macaques that have been infected with high consequence pathogens. To ensure relevance of these models we frequently challenge by the aerosol route and monitor the development of disease and protective or therapeutic efficacy by methodologies similar to those used in the clinic. We have devised methods of sampling that can inform on pathogenesis and immune function that include lung lavage and medical imaging such as computed tomography and positron emission tomography-computed tomography. Imaging assists our assessment of progression to disease whilst providing refinement in application of early humane endpoints. We have developed directional flow containment systems that provide quantifiable operator protection whilst allowing group housing and a wide range of enrichment strategies appropriate for each species. Furthermore, we have demonstrated our improvements in animal welfare through use of a software-based Animal Welfare Assessment Grid that was developed with help of NC3Rs funding and enables us to quantify the lifetime experience of animals.

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Facility design and management. Strategies for high level biocontainment

Dennis,

Charlton,

Elam

et al. 2024

Lab Anim

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A Flexible Approach to Imaging in ABSL-3 Laboratories

et al. 2015

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In-life imaging of animals challenged experimentally with infectious agents greatly enhances the quality of data gained from a pathogenesis or efficacy study. This additional information also presents an opportunity to address ethical issues by refining the studies and reducing the number of animals used. Both magnetic resonance (MR) and computed tomography (CT) imaging modalities are used extensively in human medicine to diagnose disease and to monitor the efficacy of treatments. To make animal-based studies as relevant as possible to the clinical situation, such technologies must be applied wherever possible. Imaging animals infected with disease-causing agents presents a number of challenges for programs that assure health and safety as well as the well-being of the animals during the scanning process.

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Special Housing Arrangements

Cited by 2 publications

References 27 publications

Facility design and management. Strategies for high level biocontainment

Facility design and management. Strategies for high level biocontainment

A Flexible Approach to Imaging in ABSL-3 Laboratories

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