Special Issue: Genetic Perspectives in Thyroid Cancer

Silva, Susana Nunes

doi:10.3390/genes12020126

Cited by 7 publications

(5 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although PTC has a stable high survival rate, cervical LN metastasis is prone to exist at the early stage (4)(5)(6)31). Local recurrence and distant metastasis are highly associated with cervical LN metastasis (7,8,32).…”

Section: Discussionmentioning

confidence: 99%

“…Thyroid carcinoma is one of the most common endocrine malignancies with a significantly increasing incidence in the last decade worldwide. Papillary thyroid carcinoma (PTC) accounts for more than 90% of patients with thyroid carcinoma, which has a stable high survival rate (1)(2)(3)(4)(5). However, cervical lymph node (LN) metastasis is prone to present in 40%-90% of PTC patients (6).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A radiomics nomogram for the ultrasound-based evaluation of central cervical lymph node metastasis in papillary thyroid carcinoma

et al. 2022

View full text Add to dashboard Cite

PurposeTo develop and validate a radiomics nomogram based on ultrasound (US) to predict central cervical lymph node (LN) metastasis in patients with papillary thyroid carcinoma (PTC).MethodsPTC patients with pathologically confirmed presence or absence of central cervical LN metastasis in our hospital between March 2021 and November 2021 were enrolled as the training cohort. Radiomics features were extracted from the preoperative US images, and a radiomics signature was constructed. Univariate and multivariate logistic regression analyses were used to screen out the independent risk factors, and a radiomics nomogram was established. The performance of the model was verified in the independent test cohort of PTC patients who underwent thyroidectomy and cervical LN dissection in our hospital from December 2021 to March 2022.ResultsIn the independent test cohort, the radiomics model based on long-axis cross-section and short-axis cross-section images outperformed the radiomics models based on either one of these sections (the area under the curve (AUC), 0.69 vs. 0.62 and 0.66). The radiomics signature consisted of 4 selected features. The US radiomics nomogram included the radiomics signature, age, gender, BRAF V600E mutation status, and extrathyroidal extension (ETE) status. In the independent test cohort, the AUC of the receiver operating curve(ROC) of this nomogram was 0.76, outperformingthe clinical model and the radiomics model (0.63 and 0.69, respectively), and also much better than preoperative US examination (AUC, 0.60). Decision curve analysis indicated that the radiomics nomogram was clinically useful.ConclusionsThis study presents an efficient and useful US radiomics nomogram that can provide comprehensive information to assist clinicians in the individualized preoperative prediction of central cervical LN metastasis in PTC patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A radiomics nomogram for the ultrasound-based evaluation of central cervical lymph node metastasis in papillary thyroid carcinoma

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Thyroid cancer is the most common type of endocrine cancer in women and there is an increased incidence and upward trend of mortality rate of thyroid cancer from 2000 to 2016 in China [1] . Papillary thyroid cancer (PTC) accounts for 85 %–90 % of thyroid cancer [2] . Although a majority of PTC patients have a favorable prognosis, there are still some patients who die from recurrence and distant metastasis.…”

Section: Introductionmentioning

confidence: 99%

AEBP1 promotes papillary thyroid cancer progression by activating BMP4 signaling

Ju,

Xing,

et al. 2024

Neoplasia

View full text Add to dashboard Cite

“…The development of THCA is a multistep, cascade process involving genetic mutations, immune cell and dysfunction, disrupted hormone levels, and cancer stem cells (CSC) [ [6] , [7] , [8] ]. In 1997, Bonnet et al provided the first conclusive evidence of CSC in leukemia patients, opening up new perspectives in human understanding of tumors [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Stem cell index-based RiskScore model for predicting prognosis in thyroid cancer and experimental verification

Chen,

Gao,

Liang

et al. 2024

Heliyon

View full text Add to dashboard Cite

Special Issue: Genetic Perspectives in Thyroid Cancer

Abstract: Thyroid cancer is not just a common type of cancer, it is the most frequently diagnosed endocrine malignancy worldwide [...]

Cited by 7 publications

References 8 publications

A radiomics nomogram for the ultrasound-based evaluation of central cervical lymph node metastasis in papillary thyroid carcinoma

A radiomics nomogram for the ultrasound-based evaluation of central cervical lymph node metastasis in papillary thyroid carcinoma

AEBP1 promotes papillary thyroid cancer progression by activating BMP4 signaling

Stem cell index-based RiskScore model for predicting prognosis in thyroid cancer and experimental verification

Contact Info

Product

Resources

About