Special Issue: Multifunctional Coatings in Orthopedic Implants

Hong, Qimin; Nie, Bin’en

doi:10.3390/coatings12070967

Cited by 2 publications

(1 citation statement)

References 23 publications

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“…The formation of biofilms at implants significantly impairs the efficacy of antibiotic treatment by increasing the antibiotic resistance of internal biofilm cells by 10–1000 times [ 18 ]. This necessitates efforts to design safe and efficacious strategies for targeting implant-associated infections and effectively combating the development of biofilms through implant surface modifications and the use of biomaterials with excellent anti-biofouling properties, and assist, therefore, host tissues around the implants in winning “the race for the surface” [ 19 , 20 ]. As an alternative to systemic antibiotic use, the FDA has approved various biomaterial candidates that can be used for targeting IAIs [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Antibacterial Coatings to Combat Orthopedic Implant-Associated Infections

Akay,

Yaghmur

2024

Molecules

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Implant-associated infections (IAIs) represent a major health burden due to the complex structural features of biofilms and their inherent tolerance to antimicrobial agents and the immune system. Thus, the viable options to eradicate biofilms embedded on medical implants are surgical operations and long-term and repeated antibiotic courses. Recent years have witnessed a growing interest in the development of robust and reliable strategies for prevention and treatment of IAIs. In particular, it seems promising to develop materials with anti-biofouling and antibacterial properties for combating IAIs on implants. In this contribution, we exclusively focus on recent advances in the development of modified and functionalized implant surfaces for inhibiting bacterial attachment and eventually biofilm formation on orthopedic implants. Further, we highlight recent progress in the development of antibacterial coatings (including self-assembled nanocoatings) for preventing biofilm formation on orthopedic implants. Among the recently introduced approaches for development of efficient and durable antibacterial coatings, we focus on the use of safe and biocompatible materials with excellent antibacterial activities for local delivery of combinatorial antimicrobial agents for preventing and treating IAIs and overcoming antimicrobial resistance.

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