Tumors can cause severe problem to human beings. Sometime it can be a cause of death. Earlier there were lack of treatment and technological deficiency, due to which it was unable to detect tumor cells and even unable to offer proper treatment for these diseases. This study aims to use Photonic crystal (PhC) due to their ample choice of structures and litheness to endure with every sphere of influence has been utilized them twenty decade back to now a day and have extremely huge prospects in imminent future also. They have revealed their incidence in the field of imaging, sensing, fabricating industries, automation, medical, mechatronics, computronics, mechanochromic, underwater acoustic detection, pharma industries and nanoimprinting etc. If we are discussing about current and impending applications of PhC then it comprises smart sensing and detection of disunite diseases, anonymous viruses and a range of tumors. Artificial intelligence (AI) is also playing incredibly essential role in analyzing and creating entities equivalent to the change in human behavior. AI tools and techniques are utilizing to create intelligent entities through which it is accomplishing countless feats. The PhC along with the artificial intelligence are utilizing as Optical Neural Network (ONN), Artificial Neural Network (ANN), Cellular Computing, Plasma Technology, Parallel Processing, Image Processing etc. Here in this study designated photonic crystal has been used for the detection of infected cell in human body. Sometimes these infected cells are unable to trace by normal pathological investigations and slowly they take a shape of Tumors. But thanks to Photonics crystal sensors that they have made it true not only for detection but we can say for early detection of such tumors in human body. These early detection and proper investigation is possible only because of AI impacts on photonics crystal. This study focuses on detection and observation of bio molecules for selectivity, sensitivity, reflectivity and concentration. By change in wavelength i.e. from 1.5 μm to 4 μm the refractive index (RI) of tumor cell can be measured which is observed by measuring sensitivity between 11258 nm/RIU to 32358 nm/RIU. Tumors have refractive indices varies between 1.3342 to 1.4251. It is observed that sarcoma level is directly proportional to the RI of tumor. Various AI algorithms like support vector machine (SVM) obtained accuracy as 96%, K- nearest neighbor (KNN) shows as 70%, logistic regression (LR) shows as 88%, random forest (RF) show it as 90%, fuzzy logic (FL) and artificial neural network (ANN) observed accuracy as 93% and 95% respectively.