Special Issue “Parkinson’s Disease: Genetics and Pathogenesis”

Lesage, Suzanne; Trinh, Joanne

doi:10.3390/genes14030737

Cited by 1 publication

(1 citation statement)

References 16 publications

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“…At the cellular level, α-synuclein (αSyn, encoded by the SNCA gene) aggregation is considered as the pathological hallmark of PD. In addition, increased ROS levels and impaired autophagy and mitochondria together contribute to PD pathology [ 116 , 117 , 118 ]. A number of genes were identified to associate with familial forms of PD, including SNCA , LRR 2, PINK 1 and PARK 7 [ 119 ].…”

Section: Parkinson’s Disease (Pd)mentioning

confidence: 99%

Towards Understanding Neurodegenerative Diseases: Insights from Caenorhabditis elegans

Wu,

Chen,

et al. 2023

IJMS

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The elevated occurrence of debilitating neurodegenerative disorders, such as amyotrophic lateral sclerosis (ALS), Huntington’s disease (HD), Alzheimer’s disease (AD), Parkinson’s disease (PD) and Machado–Joseph disease (MJD), demands urgent disease-modifying therapeutics. Owing to the evolutionarily conserved molecular signalling pathways with mammalian species and facile genetic manipulation, the nematode Caenorhabditis elegans (C. elegans) emerges as a powerful and manipulative model system for mechanistic insights into neurodegenerative diseases. Herein, we review several representative C. elegans models established for five common neurodegenerative diseases, which closely simulate disease phenotypes specifically in the gain-of-function aspect. We exemplify applications of high-throughput genetic and drug screenings to illustrate the potential of C. elegans to probe novel therapeutic targets. This review highlights the utility of C. elegans as a comprehensive and versatile platform for the dissection of neurodegenerative diseases at the molecular level.

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